96 results found
    1. Microbiology and Infectious Disease

    Release of human cytomegalovirus from latency by a KAP1/TRIM28 phosphorylation switch

    Benjamin Rauwel et al.
    Inactivation of KAP1 by mTOR-mediated phosphorylation releases human cytomegalovirus from latency, and has the potential to be used as a therapy to purge the virus from transplant organs.
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    Virus infection is controlled by hematopoietic and stromal cell sensing of murine cytomegalovirus through STING

    Sytse J Piersma et al.
    Cytomegaloviruses are recognized by distinct sensors depending on the infected cell type and together these sensors are essential for viral control and downstream immune responses.
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    Control of immune ligands by members of a cytomegalovirus gene expansion suppresses natural killer cell activation

    Ceri A Fielding et al.
    The human cytomegalovirus US12 gene family work co-operatively to degrade large numbers of immune ligands and prevent recognition by natural killer cells.
    1. Computational and Systems Biology
    2. Microbiology and Infectious Disease

    Human cytomegalovirus interactome analysis identifies degradation hubs, domain associations and viral protein functions

    Luis V Nobre et al.
    The human cytomegalovirus (HCMV) interactome systematically characterises high-confidence viral-viral and viral-host protein interactions in HCMV-infected cells, facilitating multiple novel insights into HCMV and herpesviral function.
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    Cytomegalovirus protein m154 perturbs the adaptor protein-1 compartment mediating broad-spectrum immune evasion

    Ivana Strazic Geljic et al.
    Single mouse cytomegalovirus protein, m154, downmodulates surface expression of numerous targets important for NK and CD8 T cell activation by perturbing adaptor protein-1 sorting and redirecting targets to lysosomal degradation.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Human cytomegalovirus IE1 protein alters the higher-order chromatin structure by targeting the acidic patch of the nucleosome

    Qianglin Fang et al.
    Distinct binding of viral proteins to the same region on the nucleosome surface can result in contrasting changes to higher-order chromatin structure in the host cell.
    1. Microbiology and Infectious Disease

    Single cell analysis reveals human cytomegalovirus drives latently infected cells towards an anergic-like monocyte state

    Miri Shnayder et al.
    Single-cell and bulk expression analyses reveal that HCMV latent infection drives cells towards a weaker immune-responsive state, which is important for its expression and reactivation.
    1. Microbiology and Infectious Disease

    The host exosome pathway underpins biogenesis of the human cytomegalovirus virion

    Declan L Turner et al.
    The HCMV virion envelope is derived from the host exosome membrane, and exosome machinery and export pathways facilitate virion egress.
    1. Microbiology and Infectious Disease

    Comprehensive annotations of human herpesvirus 6A and 6B genomes reveal novel and conserved genomic features

    Yaara Finkel et al.
    Unbiased mapping of viral open reading frames (ORFs) and transcripts in HHV-6 genomes uncovers novel ORFs and lncRNAs that are conserved across betaherpesviruses.

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