94 results found
    1. Microbiology and Infectious Disease

    The host exosome pathway underpins biogenesis of the human cytomegalovirus virion

    Declan L Turner et al.
    The HCMV virion envelope is derived from the host exosome membrane, and exosome machinery and export pathways facilitate virion egress.
    1. Cell Biology
    2. Immunology and Inflammation

    Metabolic but not transcriptional regulation by PKM2 is important for natural killer cell responses

    Jessica F Walls et al.
    Pharmacological activation of the metabolic activities of PKM2 in murine NK cells disrupts cellular redox balance and inhibits optimal NK cell effector functions.
    1. Structural Biology and Molecular Biophysics

    Slowly folding surface extension in the prototypic avian hepatitis B virus capsid governs stability

    Cihan Makbul et al.
    Duck Hepatitis B core protein forms capsids with a slowly folding extension domain which folding competence is important for viral replication.
    1. Immunology and Inflammation
    2. Neuroscience

    Drainage of inflammatory macromolecules from the brain to periphery targets the liver for macrophage infiltration

    Linlin Yang et al.
    Circulation of molecules from the brain can serve as a rapid mode of communication from the brain to the liver.
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    Virus infection is controlled by hematopoietic and stromal cell sensing of murine cytomegalovirus through STING

    Sytse J Piersma et al.
    Cytomegaloviruses are recognized by distinct sensors depending on the infected cell type and together these sensors are essential for viral control and downstream immune responses.
    1. Epidemiology and Global Health

    Proteome-wide analysis of a malaria vaccine study reveals personalized humoral immune profiles in Tanzanian adults

    Flavia Camponovo et al.
    Malaria pre-exposed volunteers exhibit large breadth of humoral immune responses, with strong variation between individuals, which might compromise vaccine-induced humoral immune response due to natural imprinting.
    1. Cancer Biology
    2. Computational and Systems Biology

    Dissecting transcriptional amplification by MYC

    Zuqin Nie et al.
    Synthetic biology experiments show that MYC is a general transcription amplifier acting at two or more sites in the transcription-cycle and that MYC-turnover contributes to its activity.
    1. Genetics and Genomics
    2. Medicine

    Does the human placenta express the canonical cell entry mediators for SARS-CoV-2?

    Roger Pique-Regi et al.
    The human placenta negligibly co-expresses the transcripts encoding the canonical cell-entry mediators for SARS-CoV-2, which explains why mothers with COVID-19 rarely transmit the virus to the fetus.
    1. Microbiology and Infectious Disease

    Structural basis for capsid recruitment and coat formation during HSV-1 nuclear egress

    Elizabeth B Draganova et al.
    Interactions were visualized between the nuclear egress complex from herpes simplex virus and a capsid protein that could promote nucleocytoplasmic translocation of the capsid in infected cells.
    1. Neuroscience

    PreBötzinger complex neurons drive respiratory modulation of blood pressure and heart rate

    Clément Menuet et al.
    The PreBötzinger complex, which contains neurons that are the kernel for inspiratory rhythm generation, also contains sympathoexcitatory and parasympathoinhibitory neurons that drive respiratory-phase oscillations in blood pressure and heart rate.

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