The GTPase Nog1 orchestrates stalk assembly, peptidyl transferase centre maturation and polypeptide exit tunnel quality control.

The deubiquitinase USP16 is associated with cytoplasmic precursors of 40S ribosomal subunits and promotes their final maturation by removal of trans-monoubiquitin from RPS27a.

Cryo-EM reveals how the central functional site of the ribosome is assembled and provides a framework to interpret the consequences of mutations linked to leukaemia-associated ribosomopathies.

Oocyte maturation and ovulation in the sister group of vertebrates, Ciona intestinalis Type A, are triggered by Ci-VP, the Ciona homolog of a typical neruopeptide, vasopressin.

In vitro and in vivo data show that C-natriuretic peptide is significant for increasing mitochondrial bioenergetics by cAMP-PKA pathway and improving cytoplasmic and nuclear maturation of maternally aged oocyte.

Endoproteolytic cleavage of the ribosomal precursor protein FUBI-eS30 is required for efficient maturation of small ribosomal subunits in the cytoplasm of human cells and involves the nucleolar deubiquitinase USP36.

Heterogeneity in cytoplasmic calcium concentration alongside B cell activation and differentiation is measured intravitally using an interdisciplinary imaging approach and novel numerical analysis.

Local coordination between shear and hydrostatic stress regulates valve shape and size.

Profiling of mRNA poly(A)-tail lengths and translational efficiencies provides new insights into posttranscriptional gene regulation in early Drosophila development.

The iRhom2 protein, a catalytically inactive relative of rhomboid proteases, controls inflammation and growth factor signalling by acting as an essential multifunctional regulatory subunit of the cell surface shedding protease TACE (ADAM17).