916 results found
    1. Neuroscience

    Alpha protocadherins and Pyk2 kinase regulate cortical neuron migration and cytoskeletal dynamics via Rac1 GTPase and WAVE complex in mice

    Li Fan et al.
    A general cytoplasmic signaling mechanism for the novel functions of diverse alpha protocadherins in cortical neuron migration and actin cytoskeletal dynamics as well as dendrite morphogenesis in the brain.
    1. Cell Biology

    Crumbs is an essential regulator of cytoskeletal dynamics and cell-cell adhesion during dorsal closure in Drosophila

    David Flores-Benitez, Elisabeth Knust
    The evolutionarily conserved polarity protein Crumbs links the regulation of cytoskeleton dynamics and cell-cell adhesion with epithelial morphogenesis.
    1. Cell Biology

    A bacteriophage tubulin harnesses dynamic instability to center DNA in infected cells

    Marcella L Erb et al.
    A bacteriophage tubulin homolog, PhuZ, forms a structure with the biochemical, structural, and functional properties of a simplified, bipolar spindle.
    1. Structural Biology and Molecular Biophysics
    2. Cell Biology

    Symmetry breaking in reconstituted actin cortices

    Enas Abu Shah, Kinneret Keren
    A reconstituted system has been developed that self-organizes into dynamic actin cortices capable of spontaneous polarization, similar to the initial cortical polarization observed in cells during embryogenesis and development.
    1. Cell Biology
    2. Developmental Biology

    miR-142 orchestrates a network of actin cytoskeleton regulators during megakaryopoiesis

    Elik Chapnik et al.
    miR-142 is instrumental for actin homeostasis, and its loss disrupts the cytoskeleton organization and thrombopoiesis of megakaryocytes.
    1. Cell Biology
    2. Developmental Biology

    Analysis of cellular behavior and cytoskeletal dynamics reveal a constriction mechanism driving optic cup morphogenesis

    María Nicolás-Pérez et al.
    High-resolution live imaging analysis shows a constriction mechanism that drives zebrafish optic cup morphogenesis and highlights the role of the extracellular matrix in transmitting tensions beyond the cellular level.
    1. Cell Biology
    2. Computational and Systems Biology

    Kinesin-4 KIF21B limits microtubule growth to allow rapid centrosome polarization in T cells

    Peter Jan Hooikaas et al.
    Kinesin-4 KIF21B promotes rapid reorientation of the microtubule network during formation of immunological synapse in T cells by acting as a pausing and catastrophe-inducing factor that keeps microtubules short.
    1. Cell Biology

    Epsin deficiency impairs endocytosis by stalling the actin-dependent invagination of endocytic clathrin-coated pits

    Mirko Messa et al.
    Epsin has a key role in the coupling of actin to endocytic clathrin coated pits that is required for their maturation and helps capture SNAREs at endocytic clathrin coated pits.
    1. Cell Biology
    2. Immunology and Inflammation

    B cells extract antigens at Arp2/3-generated actin foci interspersed with linear filaments

    Sophie I Roper et al.
    Two modes of actin polymerization, branched and linear, cooperate in B cells to extract antigens from surfaces of presenting cells.
    1. Developmental Biology

    Inter-dependent apical microtubule and actin dynamics orchestrate centrosome retention and neuronal delamination

    Ioannis Kasioulis et al.
    Microtubules are nucleated by the centrosome of the primary cilium in the apical end-foot of neuroepithelial cells and inter-dependent microtubule and actin dynamics are required here to orchestrate delamination of newborn neurons.

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