A general cytoplasmic signaling mechanism for the novel functions of diverse alpha protocadherins in cortical neuron migration and actin cytoskeletal dynamics as well as dendrite morphogenesis in the brain.
A reconstituted system has been developed that self-organizes into dynamic actin cortices capable of spontaneous polarization, similar to the initial cortical polarization observed in cells during embryogenesis and development.
High-resolution live imaging analysis shows a constriction mechanism that drives zebrafish optic cup morphogenesis and highlights the role of the extracellular matrix in transmitting tensions beyond the cellular level.
Kinesin-4 KIF21B promotes rapid reorientation of the microtubule network during formation of immunological synapse in T cells by acting as a pausing and catastrophe-inducing factor that keeps microtubules short.
Microtubules are nucleated by the centrosome of the primary cilium in the apical end-foot of neuroepithelial cells and inter-dependent microtubule and actin dynamics are required here to orchestrate delamination of newborn neurons.