Genome editing, advanced live-cell microscopy, and computational modeling were combined to measure WNT/CTNNB1 signaling parameters at the single molecule level, revealing critical regulatory nodes in this important signal transduction pathway.

Computational modeling combined with biophysical and cellular experiments reveal that rapid binding to incomplete, partial microtubule binding sites facilitates tracking of the end-binding protein EB1 with growing microtubule plus-ends.

In contrast with earlier conclusions, negative selection has a major role in cancer evolution.

The functional link between glycolytic flux, cell signalling and mesoderm patterning is investigated in mouse embryo.

Kinesin-4 KIF21B combines a processive motor activity with two non-motor microtubule-binding domains and an autoregulatory region to induce pausing of microtubule plus ends.

Unconventional secretion of a plasma membrane purine transporter via Golgi-bypass is established at an early ER-associated secretory compartment revealing that specific cargoes define alternative trafficking routes.

A mathematical model predicts that cell cycle duration acts as a transcriptional filter and directly affects cell diversity in early eukaryotic development.

ZHX2 controls HIF1α oncogenic signaling and tumorigenesis in triple-negative breast cancer.

Social clustering behaviors in Drosophila are closely tied to compensatory mechanisms for developmental traits and adaptive behavior plasticity, requiring early-life social experiences and the memory-encoding neuropeptide signaling pathway.

The pressure of fluid in the inner ear is controlled by opening of cellular valves in the endolymphatic sac to allow for regulated transepithelial fluid flow.