In models of chronic migraine, neuronal complexity is diminished in head-pain processing regions but restored through HDAC6 inhibition, which increases tubulin acetylation and cytoskeletal flexibility, and CGRP receptor blockade.
Transcriptomic analysis using a novel information-based network entropy approach provides mechanistic insights into the ability of Klotho to successfully ameliorate age-related sarcopenia in old mice, but not oldest-old mice.
Minimal essential features of Rho GTPase systems are elucidated that regulate the number of distinct domains developed by a cell’s polarity machinery, which in turn governs cell shape.
Axon guidance molecules DCC and NTN1 regulate astroglial-mediated interhemispheric remodelling required for corpus callosum formation in humans and mice.
EXOC1 contributes to the proper differentiation balance of spermatogonial stem cells and spermatocyte syncytia formation by regulating the morphology of male germ cells.
Nanoscaleimaging reveals that animal septins form dense filamentous networks on biomimeticlipid membranes, explaining how septins may regulate cell surface rigidity.
