274 results found
    1. Biochemistry and Chemical Biology
    2. Genetics and Genomics

    The long non-coding RNA Cerox1 is a post transcriptional regulator of mitochondrial complex I catalytic activity

    Tamara M Sirey, Kenny Roberts ... Chris P Ponting
    Mitochondrial energy metabolism is post-transcriptionally regulated through an interplay between long and short non-coding RNAs.
    1. Chromosomes and Gene Expression
    2. Neuroscience

    SNORD90 induces glutamatergic signaling following treatment with monoaminergic antidepressants

    Rixing Lin, Aron Kos ... Gustavo Turecki
    A small non-coding RNA, SNORD90, links monoaminergic directed antidepressant treatment with glutamatergic activation.
    1. Cell Biology

    Genetic, cellular, and structural characterization of the membrane potential-dependent cell-penetrating peptide translocation pore

    Evgeniya Trofimenko, Gianvito Grasso ... Christian Widmann
    Cationic cell-penetrating peptides (CPPs) enter cells through ~2 (–5)-nm-wide water pores induced by the strong negative plasma membrane potential that CPPs and the activity of potassium channels generate.
    1. Cell Biology
    2. Computational and Systems Biology

    Single-cell expression profiling reveals dynamic flux of cardiac stromal, vascular and immune cells in health and injury

    Nona Farbehi, Ralph Patrick ... Richard P Harvey
    Comprehensive scRNA-seq analysis of cardiac stromal cells in healthy and injured hearts reveals novel cell types and non-linear cell dynamics, providing new insights into cardiac inflammation, fibrosis and repair.
    1. Immunology and Inflammation

    The Extra-Islet Pancreas Supports Autoimmunity in Human Type 1 Diabetes

    GL Barlow, CM Schürch ... PL Bollyky
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Convincing
    1. Cell Biology
    2. Computational and Systems Biology

    Kinesin-4 KIF21B limits microtubule growth to allow rapid centrosome polarization in T cells

    Peter Jan Hooikaas, Hugo GJ Damstra ... Anna Akhmanova
    Kinesin-4 KIF21B promotes rapid reorientation of the microtubule network during formation of immunological synapse in T cells by acting as a pausing and catastrophe-inducing factor that keeps microtubules short.
    1. Developmental Biology

    Comparative single-cell profiling reveals distinct cardiac resident macrophages essential for zebrafish heart regeneration

    Ke-Hsuan Wei, I-Ting Lin ... Shih-Lei (Ben) Lai
    An extensive characterization of inflammatory cell dynamics, function, and potential interaction during zebrafish cardiac repair identified specific resident macrophage subsets function in debris clearance, inflammatory resolution, and extracellular matrix remodeling, indispensable for successful heart regeneration.
    1. Cell Biology
    2. Immunology and Inflammation

    Robust T cell activation requires an eIF3-driven burst in T cell receptor translation

    Dasmanthie De Silva, Lucas Ferguson ... Jamie HD Cate
    Binding of the translation initiation factor eIF3 to the messenger RNAs encoding the T cell receptor subunits alpha and beta is required to drive a short burst in their translation and promote a strong T cell response.

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