346 results found
    1. Genetics and Genomics
    2. Neuroscience

    Usf1, a suppressor of the circadian Clock mutant, reveals the nature of the DNA-binding of the CLOCK:BMAL1 complex in mice

    Kazuhiro Shimomura, Vivek Kumar ... Joseph S Takahashi
    A gene that codes for a transcription factor that is involved in lipid and carbohydrate metabolism also has a role in the regulation of circadian rhythms.
    1. Plant Biology

    Circadian Rhythms: Time for a change

    Sabrina E Sanchez, Marcelo J Yanovsky
    Version of Record
    Insight
    1. Neuroscience

    Dismantling the Papez circuit for memory in rats

    Seralynne D Vann
    In contrast to current models, inputs from midbrain limbic structures, but not from the hippocampus, are necessary for mammillary body contributions to memory.
    1. Neuroscience
    2. Medicine

    Common resting brain dynamics indicate a possible mechanism underlying zolpidem response in severe brain injury

    Shawniqua T Williams, Mary M Conte ... Nicholas D Schiff
    The therapeutic effects of the sleeping pill zolpidem in patients with disorders of consciousness may be due to recruitment of brain cells idling in abnormally low-frequency brain waves.
    1. Neuroscience

    Mouse rods signal through gap junctions with cones

    Sabrina Asteriti, Claudia Gargini, Lorenzo Cangiano
    Electrophysiological recordings show that cones in the eyes of mice are able to receive strong input from rods via gap junctions, supporting the view that this route plays an important role in vision.
    1. Neuroscience

    Identification of Redeye, a new sleep-regulating protein whose expression is modulated by sleep amount

    Mi Shi, Zhifeng Yue ... Amita Sehgal
    A gene found in Drosophila, and named redeye, encodes a protein that accumulates during sleep deprivation and forms part of the homeostatic system that promotes and maintains sleep.
    1. Neuroscience

    Sleep: Up all night on a redeye flight

    Leslie C Griffith
    Version of Record
    Insight
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    MicroRNAs shape circadian hepatic gene expression on a transcriptome-wide scale

    Ngoc-Hien Du, Alaaddin Bulak Arpat ... David Gatfield
    In the liver, microRNAs exert widespread functions in the modulation of phases and amplitudes of clock-controlled gene expression, but their influence on the core clock is remarkably mild.
    1. Cell Biology
    2. Plant Biology

    Natural variation reveals that intracellular distribution of ELF3 protein is associated with function in the circadian clock

    Muhammad Usman Anwer, Eleni Boikoglou ... Seth Jon Davis
    In Arabidopsis, a natural variant of the ELF3 protein, which originated in Central Asia, is less likely to accumulate in the nucleus, and causes the circadian clock to run faster and be less responsive to environmental cues.

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