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The most influential clocks within the Drosophila circadian clock neuron network form the fewest synapses within the network, and neurons that do not themselves contain molecular clocks mediate connections between those that do, suggesting a key role in timekeeping.

NRF2 is the mechanism through which oxidative signals directly input into the circadian clockwork to link metabolism and timekeeping in Mus musculus.

In the liver, microRNAs exert widespread functions in the modulation of phases and amplitudes of clock-controlled gene expression, but their influence on the core clock is remarkably mild.

Misalignment between light and temperature cycles leads to disrupted circadian behavior and a substantially altered rhythmic transcriptome.

In Arabidopsis, a natural variant of the ELF3 protein, which originated in Central Asia, is less likely to accumulate in the nucleus, and causes the circadian clock to run faster and be less responsive to environmental cues.

The time at which mice consume food can dramatically affect hippocampal-dependent biochemistry, physiology, and learned behavior.

Daily fluctuations versus transient perturbations in environmental light influence behavior and physiology through distinct circuits.

In Drosophila, key neurons controlling sleep play an important role in adjusting the temperature set-point before dawn via time-dependent neuronal plasticity within the clock circuits.

Rhythmic transcriptome analyses of human skeletal muscle tissue and cultured primary myotubes reveal an essential role for the circadian coordination of glucose homeostasis and lipid metabolism in human skeletal muscle.