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    1. Cancer Biology
    2. Epidemiology and Global Health

    Risk of second primary cancers after a diagnosis of first primary cancer: A pan-cancer analysis and Mendelian randomization study

    Xiaohao Ruan, Da Huang ... Rong Na
    A certain type of primary cancer may cause another second primary cancer which would be of clinical importance to make a personalized screening plan for certain primary cancer patients.
    1. Epidemiology and Global Health

    Prediction of type 2 diabetes mellitus onset using logistic regression-based scorecards

    Yochai Edlitz, Eran Segal
    Computational methods were used to develop accurate manual scorecards for early detection of participants at risk of type 2 diabetes based on the UK Biobank database.
    1. Computational and Systems Biology

    A computational interactome and functional annotation for the human proteome

    José Ignacio Garzón, Lei Deng ... Barry Honig
    A machine-learning approach is used to predict 1.35 million interactions for 85% of the human proteome.
    1. Computational and Systems Biology

    Genome-scale annotation of protein binding sites via language model and geometric deep learning

    Qianmu Yuan, Chong Tian, Yuedong Yang
    Integration of language model and geometric deep learning enables accurate and efficient genome-scale annotation of comprehensive protein-ligand binding sites.
    1. Computational and Systems Biology
    2. Ecology

    A rapid phylogeny-based method for accurate community profiling of large-scale metabarcoding datasets

    Lenore Pipes, Rasmus Nielsen
    Tronko provides a scalable solution for accurate taxonomic assignment for large-scale metabarcoding datasets by overcoming the speed and memory limitations of previous phylogenetic placement methods.
    1. Microbiology and Infectious Disease

    A framework for community curation of interspecies interactions literature

    Alayne Cuzick, James Seager ... Kim E Hammond-Kosack
    A framework has been devised that enables global participation in the curation of publications on any topic involving two or more living organisms, ranging from microscopic to larger sizes, in their natural or artificial environments or ecosystems.
    1. Immunology and Inflammation

    Memory persistence and differentiation into antibody-secreting cells accompanied by positive selection in longitudinal BCR repertoires

    Artem Mikelov, Evgeniia I Alekseeva ... Ivan V Zvyagin
    High degree of clonal persistence and excess of inter-individual convergence are observed in human memory B cell repertoires, along with signatures of both negative and positive selection in most abundant clonal lineages.
    1. Epidemiology and Global Health

    Estimating the burden of α-thalassaemia in Thailand using a comprehensive prevalence database for Southeast Asia

    Carinna Hockham, Supachai Ekwattanakit ... Frédéric B Piel
    The incorporation of as yet underused local epidemiological data on α-thalassaemia in Southeast Asia within a geostatistical model suggests that the burden of severe α-thalassaemia forms may have been underestimated.
    1. Computational and Systems Biology
    2. Microbiology and Infectious Disease

    Unifying the known and unknown microbial coding sequence space

    Chiara Vanni, Matthew S Schechter ... Antonio Fernàndez-Guerra
    A newly developed computational framework provides an overview of the extent, diversity, and relevance of the genes of unknown function in genomes and metagenomes.
    1. Genetics and Genomics
    2. Structural Biology and Molecular Biophysics

    Structure-guided isoform identification for the human transcriptome

    Markus J Sommer, Sooyoung Cha ... Steven L Salzberg
    The ability to accurately predict a protein's structure gives us an entirely new way to annotate the human genome.