574 results found
  1. Meta-research

    Meta-Research: A Collection of Articles

    Edited by Peter A Rodgers
    The study of science itself is a growing field of research.
  2. Image of raised hands to represent diversity

    Equity, Diversity and Inclusion

    Edited by Julia Deathridge
    The research community needs to do more to support scientists from underrepresented groups.
    1. Developmental Biology

    m6A RNA methylation impacts fate choices during skin morphogenesis

    Linghe Xi et al.
    METTL3-mediated m6A modification maintains proper cell lineage specification during skin epithelium morphogenesis by coupling transcription and translation of key regulatory pathways.
    1. Structural Biology and Molecular Biophysics
    2. Cell Biology

    An intracellular anion channel critical for pigmentation

    Nicholas W Bellono et al.
    Oculocutaneous albinism II (OCA2) contributes to a melanosome-specific anion channel that modulates organellar pH and is critical for melanin synthesis.
    1. Chromosomes and Gene Expression

    Genomic DNA transposition induced by human PGBD5

    Anton G Henssen et al.
    The human PGBD5 gene encodes an active DNA transposase.
    1. Computational and Systems Biology
    2. Ecology

    Expanding xylose metabolism in yeast for plant cell wall conversion to biofuels

    Xin Li et al.
    Parallel pathways of xylose metabolism identified in fungi that grow on plants can be used in yeast to promote hemicellulose conversion to biofuels.
    1. Cell Biology
    2. Developmental Biology

    Dynamics of primitive streak regression controls the fate of neuromesodermal progenitors in the chicken embryo

    Charlene Guillot et al.
    Inverse gradients of cell ingression and division in the epiblast allow the bipotent progenitors in the anterior streak to become the main progenitors for posterior axis formation from the tail bud.
    1. Evolutionary Biology
    2. Genetics and Genomics

    The evolutionary plasticity of chromosome metabolism allows adaptation to constitutive DNA replication stress

    Marco Fumasoni, Andrew W Murray
    Evolutionary adaptation to a constitutive perturbation of DNA replication reveals that adaptive mutations in three conserved pathways interact to restore faithful chromosome replication and segregation.
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    Systematic perturbation of retroviral LTRs reveals widespread long-range effects on human gene regulation

    Daniel R Fuentes et al.
    A new approach combines guide RNA multiplexing with CRISPR activation and interference to facilitate functional studies of transposable elements present in hundreds of copies throughout the human genome.
    1. Cancer Biology
    2. Cell Biology

    Different promoter affinities account for specificity in MYC-dependent gene regulation

    Francesca Lorenzin et al.
    Differences in promoter affinity and MYC levels explain distinct expression profiles induced by physiological and oncogenic MYC.

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