Fertilizing mouse spermatozoa, characterized by intact CatSper channels, lack of protein tyrosine phosphorylation, and reacted acrosomes, in the female reproductive tract provide molecular insight into sperm selection for successful fertilization.

The use of network science to quantify the properties of global cellular organization in the plant hypocotyl identifies higher-order properties and plasticity in epidermal cell patterning.

The mode of binding and cellular effect of the first FOXO3-DNA-binding-domain targeting small compound discovered by a combined pharmacophore-based/biochemical screening approach is reported.

A major consequence of ductal-to-squamous lineage transition in pancreatic cancer cells is to augment inflammation, which may explain the exceptionally poor clinical outcomes of squamous-subtype tumors.

Viral evolution can lead to mutations that render specific glycosylation sites dispensable for folding and for supporting the protein's function, allowing changes in the shield, and in the immunogenic profile.

The C. elegans canonical DBL1/TGFβ signaling pathway is not only regulated in response to bacterial challenges, but also appropriately tailors behaviors and molecular immune responses to bacterial challenges, and animals lacking DBL1 respond to specific bacteria as more harmful.

The target-myristoyl switch induced by protein-protein interaction is a novel regulatory mechanism for myristoylated EF-hand calcium-binding proteins, in which target binding facilitates exposure of the myristoyl anchor and the association to the lipid membrane in a calcium-independent manner.

Cytological analyses combined with in vitro liposome reconstitution reveal that yeast SUN domain protein, Mps3, shows meiosis-specific phosphorylation in the luminal region of the nuclear envelope during meiosis for chromosome motion and nuclear envelope remodelling.

Distinct metabolic states coupled with differing morphogen levels regulate HC morphology along the tonotopic axis of the developing chick auditory organ.

Using bioinformatic and biochemical approaches, the study has explained the discriminator base anomaly in bacterial tRNA(Gly) through identification of the key determinant of DTD specificity.