Simultaneous targeting of loci by pathways that promote euchromatin and heterochromatin primes transcribed genes for epimutations in the form of CG DNA methylation.
A novel lncRNA (Ephemeron) is connected to known post-transcriptional and epigenetic regulators as part of an integrated machinery, which controls the timely exit from the naïve state of mouse embryonic stem cells.
Bioinformatics analyses reveal that the Krüppel-associated box domain zinc finger proteins are associated with DNA methylation of retroelements in human primordial germ cells which highlight potential molecular mechanisms for the regulation of retroelements in human male germ cells.
Ellen N Elliott, Karyn L Sheaffer, Klaus H Kaestner
The maintenance methyltransferase Dnmt1 and the de novo methyltransferase Dnmt3b cooperate to maintain DNA methylation and genomic stability in the adult intestinal epithelium.
Correction of the DNA methyltransferase 3B gene in ICF1 syndrome fails to rescue the abnormal DNA hypomethylation at subtelomeric regions due to accompanied epigenetic abnormalities in these regions.
Junhao Li, Antonio Pinto-Duarte ... M Margarita Behrens
Loss of Dnmt3a in excitatory neurons disrupts synaptic morphology and behavior, and triggers the expansion of H3K27me3 binding, suggestive of increased polycomb repression.