174 results found
    1. Developmental Biology

    A lncRNA fine tunes the dynamics of a cell state transition involving Lin28, let-7 and de novo DNA methylation

    Meng Amy Li et al.
    A novel lncRNA (Ephemeron) is connected to known post-transcriptional and epigenetic regulators as part of an integrated machinery, which controls the timely exit from the naïve state of mouse embryonic stem cells.
    1. Developmental Biology
    2. Genetics and Genomics

    In vivo targeting of de novo DNA methylation by histone modifications in yeast and mouse

    Marco Morselli et al.
    DNA methylation deposition is dependent on the presence of H3K4me3 and H3K36me3 histone marks.
    1. Chromosomes and Gene Expression
    2. Plant Biology

    Epimutations are associated with CHROMOMETHYLASE 3-induced de novo DNA methylation

    Jered M Wendte et al.
    Simultaneous targeting of loci by pathways that promote euchromatin and heterochromatin primes transcribed genes for epimutations in the form of CG DNA methylation.
    1. Chromosomes and Gene Expression

    Identification of Pol IV and RDR2-dependent precursors of 24 nt siRNAs guiding de novo DNA methylation in Arabidopsis

    Todd Blevins et al.
    The 24-nucleotide long siRNAs that guide cytosine methylation in Arabidopsis are made by dicing short double-stranded RNAs that are only around 30 nucleotides long.
    1. Developmental Biology

    Epigenetic regulation of hematopoiesis by DNA methylation

    Aniket V Gore et al.
    Methylation of a key transcription factor gene by a de novo DNA methyltransferase assures the maintenance of hematopoietic stem cell fate.
    1. Developmental Biology

    The ‘de novo’ DNA methyltransferase Dnmt3b compensates the Dnmt1-deficient intestinal epithelium

    Ellen N Elliott et al.
    The maintenance methyltransferase Dnmt1 and the de novo methyltransferase Dnmt3b cooperate to maintain DNA methylation and genomic stability in the adult intestinal epithelium.
    1. Developmental Biology
    2. Evolutionary Biology

    An integrative genomic analysis of the Longshanks selection experiment for longer limbs in mice

    João PL Castro et al.
    Genome sequencing of mice selected for longer limbs reveals that rapid selection response is due to both discrete loci and polygenic adaptation.
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    Dynamic enhancer partitioning instructs activation of a growth-related gene during exit from naïve pluripotency

    Maxim Greenberg et al.
    Three-dimensional chromatin architecture facilitates a promoter switch in order to ensure maintained expression of a gene involved in growth during embryonic stem cell differentiation.
    1. Genetics and Genomics
    2. Stem Cells and Regenerative Medicine

    The novel lncRNA lnc-NR2F1 is pro-neurogenic and mutated in human neurodevelopmental disorders

    Cheen Euong Ang et al.
    lnc-Nr2f1, a long non-coding RNA focally deleted in autism patients, directly occupies and regulates neuronal genes.

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