334 results found
    1. Developmental Biology
    2. Genetics and Genomics

    In vivo targeting of de novo DNA methylation by histone modifications in yeast and mouse

    Marco Morselli, William A Pastor ... Matteo Pellegrini
    DNA methylation deposition is dependent on the presence of H3K4me3 and H3K36me3 histone marks.
    1. Chromosomes and Gene Expression
    2. Plant Biology

    Epimutations are associated with CHROMOMETHYLASE 3-induced de novo DNA methylation

    Jered M Wendte, Yinwen Zhang ... Robert J Schmitz
    Simultaneous targeting of loci by pathways that promote euchromatin and heterochromatin primes transcribed genes for epimutations in the form of CG DNA methylation.
    1. Developmental Biology

    A lncRNA fine tunes the dynamics of a cell state transition involving Lin28, let-7 and de novo DNA methylation

    Meng Amy Li, Paulo P Amaral ... Austin Smith
    A novel lncRNA (Ephemeron) is connected to known post-transcriptional and epigenetic regulators as part of an integrated machinery, which controls the timely exit from the naïve state of mouse embryonic stem cells.
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    Potential role of KRAB-ZFP binding and transcriptional states on DNA methylation of retroelements in human male germ cells

    Kei Fukuda, Yoshinori Makino ... Yoichi Shinkai
    Bioinformatics analyses reveal that the Krüppel-associated box domain zinc finger proteins are associated with DNA methylation of retroelements in human primordial germ cells which highlight potential molecular mechanisms for the regulation of retroelements in human male germ cells.
    1. Developmental Biology

    The ‘de novo’ DNA methyltransferase Dnmt3b compensates the Dnmt1-deficient intestinal epithelium

    Ellen N Elliott, Karyn L Sheaffer, Klaus H Kaestner
    The maintenance methyltransferase Dnmt1 and the de novo methyltransferase Dnmt3b cooperate to maintain DNA methylation and genomic stability in the adult intestinal epithelium.
    1. Genetics and Genomics
    2. Stem Cells and Regenerative Medicine

    Global DNA methylation remodeling during direct reprogramming of fibroblasts to neurons

    Chongyuan Luo, Qian Yi Lee ... Joseph R Ecker
    Induced neuronal cells acquire epigenomic signatures specific to matured neurons.
    1. Chromosomes and Gene Expression
    2. Plant Biology

    DDM1 and Lsh remodelers allow methylation of DNA wrapped in nucleosomes

    David B Lyons, Daniel Zilberman
    Nucleosomes and linker histones block eukaryotic cytosine methylation.
    1. Stem Cells and Regenerative Medicine

    Persistent epigenetic memory impedes rescue of the telomeric phenotype in human ICF iPSCs following DNMT3B correction

    Shir Toubiana, Miriam Gagliardi ... Sara Selig
    Correction of the DNA methyltransferase 3B gene in ICF1 syndrome fails to rescue the abnormal DNA hypomethylation at subtelomeric regions due to accompanied epigenetic abnormalities in these regions.
    1. Genetics and Genomics
    2. Neuroscience

    Dnmt3a knockout in excitatory neurons impairs postnatal synapse maturation and increases the repressive histone modification H3K27me3

    Junhao Li, Antonio Pinto-Duarte ... M Margarita Behrens
    Loss of Dnmt3a in excitatory neurons disrupts synaptic morphology and behavior, and triggers the expansion of H3K27me3 binding, suggestive of increased polycomb repression.

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