984 results found
    1. Genetics and Genomics

    Fast turnover of genome transcription across evolutionary time exposes entire non-coding DNA to de novo gene emergence

    Rafik Neme, Diethard Tautz
    Deep sequencing of transcriptomes from closely related taxa shows that the whole genome can become subject to evolutionary testing within a short time frame via de novo evolution of genes.
    1. Evolutionary Biology

    Long non-coding RNAs as a source of new peptides

    Jorge Ruiz-Orera et al.
    Ribosome profiling data from several eukaryotic species provides strong evidence that many long non-coding RNA molecules encode novel short proteins.
    1. Computational and Systems Biology
    2. Evolutionary Biology

    Expression noise facilitates the evolution of gene regulation

    Luise Wolf et al.
    In-lab evolution of synthetic promoters has revealed a novel general mechanism for de novo evolution of gene regulation, and highlights the crucial role of expression noise in this process.
    1. Ecology
    2. Human Biology and Medicine

    Point of View: A transatlantic perspective on 20 emerging issues in biological engineering

    Bonnie C Wintle et al.
    Horizon scanning has been used to identify opportunities and risks presented by 20 emerging issues in the field of biological engineering.
    1. Evolutionary Biology
    2. Genetics and Genomics

    Spermatogenesis: A hotspot for new genes

    Anne-Marie Dion-Côté
    Single-cell RNA-sequencing in fruit flies gives an unprecedented picture of how new genes are expressed during the formation of sperm.
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    1. Evolutionary Biology
    2. Genetics and Genomics

    Philosophy of Biology: The meanings of 'function' in biology and the problematic case of de novo gene emergence

    Diane Marie Keeling et al.
    A lexicon to help scientists and philosophers discuss the meaning of function in molecular biology more clearly is proposed.
    1. Developmental Biology
    2. Stem Cells and Regenerative Medicine

    Regeneration: Lymphatic vessels help mend broken hearts

    Catherine Pfefferli, Anna Jaźwińska
    Experiments on zebrafish show that the regeneration of the heart after an injury depends on lymphatic vessels.
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    1. Plant Biology

    Antimicrobial peptide expression in a wild tobacco plant reveals the limits of host-microbe-manipulations in the field

    Arne Weinhold et al.
    The attempt to manipulate a microbiome in planta to study the ecological consequences under field conditions leaves plants and their microbes surprisingly unimpressed.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Proteasome storage granules protect proteasomes from autophagic degradation upon carbon starvation

    Richard S Marshall, Richard D Vierstra
    Proteasomes are protected from autophagic elimination upon carbon starvation by sequestration into cytoplasmic storage granules, which aid cell fitness by providing a cache of proteasomes that can be rapidly remobilized when carbon availability improves.
    1. Chromosomes and Gene Expression

    Cooperative interactions enable singular olfactory receptor expression in mouse olfactory neurons

    Kevin Monahan et al.
    Biochemical and genetic experiments show that Ebf and Lhx2 cooperate to specify olfactory receptor enhancers, which cooperate to drive olfactory receptor expression.

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