2,011 results found
    1. Biochemistry and Chemical Biology
    2. Microbiology and Infectious Disease

    Sodium taurocholate cotransporting polypeptide is a functional receptor for human hepatitis B and D virus

    Huan Yan, Guocai Zhong ... Wenhui Li
    Biochemical and genetic tests have revealed that a liver protein called NTCP is a functional receptor for hepatitis B and D viruses, which should lead to an improved understanding of the infections caused by these viruses and assist the development of new intervention strategies.
    1. Microbiology and Infectious Disease

    Population structuring of multi-copy, antigen-encoding genes in Plasmodium falciparum

    Yael Artzy-Randrup, Mary M Rorick ... Mercedes Pascual
    Mathematical modeling shows that local populations of the malaria parasite self-organize into a limited number of transient but distinct strains through competition for hosts in immunity space.
    1. Biochemistry and Chemical Biology
    2. Cancer Biology

    Doxorubicin blocks proliferation of cancer cells through proteolytic activation of CREB3L1

    Bray Denard, Ching Lee, Jin Ye
    Cleavage of a membrane-bound transcription factor by the chemotherapeutic reagent doxorubicin can block the proliferation of tumor cells.
    1. Structural Biology and Molecular Biophysics

    Ribosome structures to near-atomic resolution from thirty thousand cryo-EM particles

    Xiao-chen Bai, Israel S Fernandez ... Sjors HW Scheres
    A combination of direct-electron detectors and statistical movie processing allows ribosome cryo-EM structures to be determined to resolutions that were previously only attainable by X-ray crystallography.
    1. Structural Biology and Molecular Biophysics

    De novo modeling of the F420-reducing [NiFe]-hydrogenase from a methanogenic archaeon by cryo-electron microscopy

    Deryck J Mills, Stella Vitt ... Janet Vonck
    The structure of a large hydrogenase complex involved in the production of methane by microbes has been determined with cryo-electron microscopy.
    1. Developmental Biology
    2. Neuroscience

    Sox10-dependent neural crest origin of olfactory microvillous neurons in zebrafish

    Ankur Saxena, Brian N Peng, Marianne E Bronner
    Sensory neurons in the olfactory system develop from two different regions of the ectoderm, the olfactory placode and the cranial neural crest, whereas sensory neurons within the eye and ear develop from just one region.
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    Contributions of mast cells and vasoactive products, leukotrienes and chymase, to dengue virus-induced vascular leakage

    Ashley L St John, Abhay PS Rathore ... Soman N Abraham
    Proteins produced by mast cells modulate the permeability of blood vessels, and may determine whether patients infected with dengue virus develop life-threatening complications.
    1. Cell Biology
    2. Cancer Biology

    A role for PVRL4-driven cell–cell interactions in tumorigenesis

    Natalya N Pavlova, Christian Pallasch ... Stephen J Elledge
    A protein called PVRL4 has a central role in a number of cancers that originate in epithelial tissue, and anti-PVRL4 antibodies could be used to treat some of these cancers.
    1. Ecology
    2. Neuroscience

    Feeding-induced rearrangement of green leaf volatiles reduces moth oviposition

    Silke Allmann, Anna Späthe ... Bill S Hansson
    The ability of Manduca moths to recognize changes in the profile of volatile compounds released by plants being attacked by Manduca caterpillars allows them to lay their eggs on plants that are less likely to be attacked by insects and other predators, and to avoid competing against other caterpillars of the same species for resources.
    1. Developmental Biology

    A novel sphingolipid-TORC1 pathway critically promotes postembryonic development in Caenorhabditis elegans

    Huanhu Zhu, Huali Shen ... Min Han
    A lipid acts to promote the development of nematode worm larvae through activation of an enzyme complex called TORC1.

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