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Single-cell RNA-sequencing and germline substitutions provide novel insights into how testis is a hotspot for evolutionary innovation of genes, expression, and mutation at the single-cell level.

Comparative genomics and three-dimensional protein modelling identify homologs of insect chemosensory receptors in unicellular eukaryotes and plants.

A paternal bias in germline mutation is seen throughout amniotes and may be explained by sex differences in DNA damage and repair after primordial germ cell specification.

Human liver organoids provide a patient-derived platform to interrogate host and viral mechanisms of HBV replication, perform anti-HBV and toxicity drug screens, and investigate the molecular determinants of related tumorigenesis.

Ribosome profiling data from several eukaryotic species provides strong evidence that many long non-coding RNA molecules encode novel short proteins.

SCCmec genomic islands encode a novel primase-helicase pair in which priming ability is conferred upon an A-family DNA polymerase domain by a novel protein cofactor.

TRIM37 prevents the formation of centriolar protein assemblies through an atypical de novo assembly pathway that would otherwise threaten genome integrity.

Protein structures with complex topologies can be designed by recombining small independently folded domains.

Designer transmembrane peptides precisely control chimeric antigen receptor signaling strength and are insulated from undesired interactions with endogenous receptors.