1,121 results found
    1. Structural Biology and Molecular Biophysics

    De novo design of a homo-trimeric amantadine-binding protein

    Jooyoung Park et al.
    The first successful de novo design of a homo-trimeric protein that binds a C3 symmetric small molecule larger than a metal ion is an advance for computational protein design.
  1. Point of View: Four erroneous beliefs thwarting more trustworthy research

    Mark Yarborough et al.
    Strategies to improve public trust in biomedical research are being hindered by a scientific mindset that stifles interest in reform.
    1. Ecology
    2. Human Biology and Medicine

    Point of View: A transatlantic perspective on 20 emerging issues in biological engineering

    Bonnie C Wintle et al.
    Horizon scanning has been used to identify opportunities and risks presented by 20 emerging issues in the field of biological engineering.
    1. Evolutionary Biology
    2. Genetics and Genomics

    Philosophy of Biology: The meanings of 'function' in biology and the problematic case of de novo gene emergence

    Diane Marie Keeling et al.
    A lexicon to help scientists and philosophers discuss the meaning of function in molecular biology more clearly is proposed.
    1. Microbiology and Infectious Disease

    A single regulator NrtR controls bacterial NAD+ homeostasis via its acetylation

    Rongsui Gao et al.
    Functional definition of NrtR and the discovery of its acetylation represents a first paradigm for linking protein acetylation to bacterial central NAD+ metabolism.
    1. Evolutionary Biology
    2. Genetics and Genomics

    The role of structural pleiotropy and regulatory evolution in the retention of heteromers of paralogs

    Axelle Marchant et al.
    Regulatory evolution allows paralogs to escape from strucural pleiotropy.
    1. Evolutionary Biology
    2. Genetics and Genomics

    A de novo evolved gene in the house mouse regulates female pregnancy cycles

    Chen Xie et al.
    A female specifically expressed new protein-coding gene that has emerged out of non-coding sequences without detectable signatures of adaptive evolution affects female pregnancy cycles.
    1. Genetics and Genomics
    2. Neuroscience

    Taar1 gene variants have a causal role in methamphetamine intake and response and interact with Oprm1

    Alexandra M Stafford et al.
    The trace amine-associated receptor 1 gene has a causal role in methamphetamine intake and thermal response, and interacts with the mu-opioid receptor gene in its methamphetamine addiction-related effects.
    1. Genetics and Genomics
    2. Plant Biology

    The MADS-box transcription factor PHERES1 controls imprinting in the endosperm by binding to domesticated transposons

    Rita A Batista et al.
    Jumping of transposable elements provides DNA-binding sites for the MADS-box transcription factor PHERES1, allowing the regulation of imprinted genes and other key endosperm development genes.
    1. Microbiology and Infectious Disease

    Neighbor predation linked to natural competence fosters the transfer of large genomic regions in Vibrio cholerae

    Noémie Matthey et al.
    Whole-genome sequencing reveals the remarkable extent of horizontally moving genetic material in naturally competent Vibrio cholerae after a prey-killing DNA acquisition process.

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