Maternal obesity mouse model reveal that melatonin deficiency causes the genomic hyper-methylation of oocytes via increasing the expression of DNA methyltransferases.
T-regulatory type 1 cells inherit a broad repertoire of epigenetic marks from T-follicular helper T-cells, offering new insights into the developmental biology of this subset.
Georgia Maria Sagia, Xenia Georgiou ... Sofia Dimou
Unconventional secretion of a plasma membrane purine transporter via Golgi-bypass is established at an early ER-associated secretory compartment revealing that specific cargoes define alternative trafficking routes.
Clément Mazeaud, Stefan Pfister ... Laurent Chatel-Chaix
Through interactions with viral RNA and NS5, Zika virus changes the composition of the IGF2BP2-containing ribonucleoprotein complex for the benefit of the viral RNA amplification step of its life cycle.
SIRT4 regulates cellular communication network factor 2 expression through U2 small nuclear RNA auxiliary factor 2-mediated pre-mRNA splicing, presenting a potential therapeutic target for kidney fibrosis.
Typhaine Comyn, Thomas Preat ... Pierre-Yves Plaçais
In neurons of the Drosophila brain’s memory center, PKCδ relays a post-learning dopamine signal to mitochondria, boosting their metabolic activity and thereby unlocking long-term memory formation.
Philipp H Schiffer, Paschalis Natsidis ... Maximilian J Telford
A genome analysis of Xenoturbella bocki provides insights into the biology of this enigmatic marine worm and enhances our understanding of early bilaterian evolution.
Ester Vazquez-Fernandez, Jing Yang ... David Barford
The yeast APC/C cryo-EM structure reveals substantial similarities with the human APC/C structure but also important differences in mechanisms of phosphorylation-dependent regulation and activation by coactivators.
