Two novel mutations in the GRIN2B gene reduce glutamate affinity by >1000-fold, reduce the receptors proton-sensitivity, and exert a dominant-negative effect over receptors in neurons.
Multiple independent analyses reveal that a specific membrane lipid directly interacts with the signalling protein Wingless to promote synapse growth at the Drosophila neuromuscular junctions.
Cystathionine-β-synthase is a novel metabolic regulator of AKT-induced senescence and a potential tumor suppressor in gastric cancer pathogenesis which can be harnessed to target PI3K/AKT-driven cancers.
Cell biological, biochemical, and genetic analyses reveal that PLK4 controls two different phospho-dependent binding interactions that act together to promote procentriole assembly.
Breast cancer resistant to either doxorubicin or epirubicin relies on distinct primary metabolic processes, which can be targeted to reduce cancer progression.
Rapamycin treatment inhibits mTOR activity and preserves ATP levels in neurons derived from induced pluripotent stem cells from a maternally inherited Leigh syndrome patient.
Osteoblasts utilize an elegant mechanism by which they obtain and subsequently synthesize the requisite amino acids to support osteoblast differentiation and bone formation.
TADR (torn and diminished rhabdomeres)-dependent histidine transporting is required for de novo synthesis of histamine and for maintaining synaptic transmission of photoreceptor neurons in Drosophila.
