160 results found
    1. Chromosomes and Gene Expression

    General decapping activators target different subsets of inefficiently translated mRNAs

    Feng He et al.
    Dhh1, Pat1, and Lsm1 target subsets of cellular mRNAs for decapping via interactions of these regulatory proteins with the C-terminal domain of Dcp2, the catalytic component of the decapping enzyme.
    1. Structural Biology and Molecular Biophysics

    Structural model for differential cap maturation at growing microtubule ends

    Juan Estévez-Gallego et al.
    The tubulin GTPase cycle structurally modulates the microtubule cap, causing lattice expansion, which is an intermediate state involved in phosphate release and regulatory signaling.
    1. Structural Biology and Molecular Biophysics

    Limited dishevelled/Axin oligomerization determines efficiency of Wnt/β-catenin signal transduction

    Wei Kan et al.
    In vitro and in cellulo characterization of oligomerization by the cytoplasmic Wnt effector dishevelled and its partner Axin provide new mechanistic principles for Wnt/β-catenin signaling.
    1. Neuroscience

    Medial entorhinal cortex activates in a traveling wave in the rat

    J Jesús Hernández-Pérez et al.
    The existence of traveling waves in the medial entorhinal cortex, like those observed in the hippocampus, supports the hypothesis that traveling waves coordinate the activity of anatomically distributed circuits.
    1. Cell Biology

    TORC2-Gad8-dependent myosin phosphorylation modulates regulation by calcium

    Karen Baker et al.
    IQ domain phosphorylation regulates calmodulin binding and myosin-1 function.
    1. Chromosomes and Gene Expression
    2. Computational and Systems Biology

    Transcriptome maps of general eukaryotic RNA degradation factors

    Salma Sohrabi-Jahromi et al.
    Mapping of 30 general RNA degradation factors onto the yeast transcriptome provides the global distribution of factors for RNA turnover and surveillance in a eukaryotic cell.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Proteotoxicity from aberrant ribosome biogenesis compromises cell fitness

    Blake W Tye et al.
    Rapidly proliferating cells are at risk of compromised cell fitness due to proteostasis collapse from perturbations that interfere with ribosome biogenesis.
    1. Computational and Systems Biology
    2. Neuroscience

    Biophysical mechanisms in the mammalian respiratory oscillator re-examined with a new data-driven computational model

    Ryan S Phillips et al.
    Computational modeling motivated by recent experiments clarifies biophysical mechanisms generating the rhythm and amplitude of breathing at the level of neurons and brain circuits in mammals.
    1. Neuroscience

    Feedback optimizes neural coding and perception of natural stimuli

    Chengjie G Huang et al.
    Neurophysiological and behavioral approaches reveal how coordinated input from descending pathways shapes the tuning properties of electrosensory neurons in order to optimize coding of natural stimuli through temporal whitening.
    1. Developmental Biology

    Wnt11 directs nephron progenitor polarity and motile behavior ultimately determining nephron endowment

    Lori L O'Brien et al.
    Wnt11 maintains nephron progenitor niche integrity during kidney development through its modulation of cellular dynamics.

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