158 results found
    1. Ecology
    2. Physics of Living Systems

    Nutrient levels and trade-offs control diversity in a serial dilution ecosystem

    Amir Erez et al.
    Whereas theories of ecological diversity mostly consider continuously supplied nutrients, a seasonal model uncovers a general mechanism that controls diversity and reconciles conflicting experimental findings.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Atomic structure of a mitochondrial complex I intermediate from vascular plants

    Maria Maldonado et al.
    The first atomic resolution structure of a mitochondrial respiratory complex from plants provides insight into the assembly and evolution of respiration in autotrophic eukaryotes.
    1. Genetics and Genomics

    Telomeres: Getting to grips with circular chromosomes

    Constance Nugent, Katsunori Sugimoto
    A strain of budding yeast that contains one large chromosome reveals how the telomere capping complex CST maintains linear but not circular chromosomes.
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    1. Genetics and Genomics

    Cdc13 is predominant over Stn1 and Ten1 in preventing chromosome end fusions

    Zhi-Jing Wu et al.
    Cdc13 prevents chromosomes from end-to-end fusion.
    1. Medicine

    Long non-coding RNAs in regulation of adipogenesis and adipose tissue function

    Tiziana Squillaro et al.
    An update on the role of lncRNAs in adipogenesis and adipose tissue function, aimed at promoting the identification of new drug targets for obesity and metabolic diseases.
    1. Cell Biology

    A quantitative inventory of yeast P body proteins reveals principles of composition and specificity

    Wenmin Xing et al.
    Quantitative analyses of yeast P bodies reveals a small number of highly concentrated proteins and many weakly concentrated proteins, suggesting that the compartments are compositionally simpler than previously thought.
    1. Structural Biology and Molecular Biophysics

    Mechanical inhibition of isolated Vo from V/A-ATPase for proton conductance

    Jun-ichi Kishikawa et al.
    Cryo-EM structures of rotary V-ATPase reveal the ON-OFF switching mechanism of H+ translocation in the Vo membrane domain.
    1. Chromosomes and Gene Expression

    Distinct interactions of eIF4A and eIF4E with RNA helicase Ded1 stimulate translation in vivo

    Suna Gulay et al.
    Interactions of eIF4A and eIF4E with specific amino-acids in the N-terminal domain of DEAD-box helicase Ded1 enhance bulk polysome assembly and translation of reporter mRNAs with structured leaders in vivo.
    1. Neuroscience

    Gradients in the biophysical properties of neonatal auditory neurons align with synaptic contact position and the intensity coding map of inner hair cells

    Alexander L Markowitz, Radha Kalluri
    The biophysical diversity that is intrinsic to spiral ganglion neurons emerges as spatial gradients during early post-natal development and endures through subsequent maturation to likely contribute to sound intensity coding.
    1. Chromosomes and Gene Expression

    A non-canonical role for the EDC4 decapping factor in regulating MARF1-mediated mRNA decay

    William R Brothers et al.
    Crosslink immunopreciptiation (iCLIP) studies reveal important mechanistic insights into how MARF1 post-transcriptionally regulates targeted mRNAs and uncover a novel mode by which EDC4 regulates mRNA metabolism.

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