Dynamic changes in activity and connectivity of the human subthalamic nucleus reflect whether a decision will be made in haste or with caution.

In environments that fluctuate over the course of deliberation, optimal decision strategies display novel dynamics that can explain human response behaviors better than commonly used alternatives.

To establish a trade-off between the speed and accuracy of a decision, neurons in lateral intraparietal cortex combine evidence bearing on the decision with a signal that incorporates the cost of time into the decision-making process.

The calibration of decision thresholds will provide evidence for the optimal use of in silico predictors for the standardised classification of globin gene variants under the American College of Medical Genetics and Genomics/Association for Molecular Pathology framework.

A bioinformatics approach shows how to reduce noise in single-cell TCR-pMHC specificity data while retaining sensitivity toward cross-binding events to facilitate investigation of the rules governing TCR-pMHC binding.

A single framework of bounded evidence accumulation resolves the seemingly paradoxical effects of noise on accuracy, reaction time and confidence.

Non-invasive disinhibition of the oculomotor system shows that ongoing preparatory activity in the superior colliculus has movement-generating potential and need not rise to threshold in order to produce a saccade.

Firing rate nonlinearity recovers linear decodability of orientation information from simple cells of the primary visual cortex under uncertainty of nuisance parameters phase and spatial frequency.

The decision to commit to cell division-the Start transition-in budding yeast is governed by time integration of G1 cyclin-CDK activity by the transcription factor Whi5.

Computational modeling shows how neural mechanisms for mitigating biological constraints (such as neurons’ limited firing range) may eventually result in complex though predictable irrational behavior.