A data-reduced neuro-behavioral geometry in psychosis spectrum disorders mapped symptoms stably on to distinct functional brain regions and offers a framework for informing personalized treatment selection decisions.
Jamie L Courtland, Tyler WA Bradshaw ... Scott H Soderling
Cellular etiology of a human WASH complex mutation in mice reveals its specific roles in neuronal organelle trafficking and a surprising role in motor impairments.
Austin R Graves, Richard H Roth ... Richard L Huganir
A knockin mouse line was made to label endogenous AMPA receptors, enabling direct observation of synaptic plasticity in behaving animals with single-synapse resolution across the entire brain.
Shin-ya Takemura, Yoshinori Aso ... Louis K Scheffer
Connectomic analysis in the fly's (Drosophila) learning and memory center identifies unique circuit motifs that have not been anticipated by over 30 years of extensive anatomical, experimental and theoretical studies.
Adam J Harrington, Aram Raissi ... Christopher W Cowan
Mice that lack the autism- and schizophrenia-linked gene MEF2C in cortical neurons have an imbalance of excitatory and inhibitory synapses, and impaired social and cognitive abilities.
Sara Garbarino, Marco Lorenzi ... Daniel C Alexander
Computational-driven, imaging-based topological profiles of neurodegeneration differ substantially in different neurodegenerative conditions, suggesting distinct modes of dependence of the pathological spread on the underlying connectivity.
In teleost fishes, the independent evolution of electrosensory systems was repeatedly associated with evolutionary changes in brain region scaling that were independent of changes in brain–body allometry.