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    1. Evolutionary Biology
    2. Microbiology and Infectious Disease

    Genetic determinants facilitating the evolution of resistance to carbapenem antibiotics

    Peijun Ma et al.
    High-level transposon insertional mutagenesis and a broader spectrum of resistance-conferring mutations for selected carbapenems facilitate the evolution of carbapenem resistance in Klebsiella pneumonia clinical isolates.
    1. Microbiology and Infectious Disease

    Inverse regulation of Vibrio cholerae biofilm dispersal by polyamine signals

    Andrew A Bridges, Bonnie L Bassler
    The global pathogen Vibrio cholerae monitors environmental polyamines to garner information about numbers of ‘self’ versus ‘other’ in the vicinity, and in response, to remain or disperse from biofilms.
    1. Neuroscience

    Rapid recycling of glutamate transporters on the astroglial surface

    Piotr Michaluk et al.
    Rapid membrane turnover is the main 'redeployment' route for the immobile fraction of surface-expressed astroglial glutamate transporters that confine excitatory transmission to the synaptic cleft.
    1. Biochemistry and Chemical Biology
    2. Microbiology and Infectious Disease

    NusG is an intrinsic transcription termination factor that stimulates motility and coordinates gene expression with NusA

    Zachary F Mandell et al.
    The general transcription elongation factor NusG functions as an intrinsic termination factor in Bacillus subtilis and together with NusA coordinates global gene expression including the motility regulon.
    1. Medicine
    2. Structural Biology and Molecular Biophysics

    Allosteric communication in class A β-lactamases occurs via cooperative coupling of loop dynamics

    Ioannis Galdadas et al.
    A combination of equilibrium and nonequilibrium molecular dynamics simulations is an effective tool to study allosteric communications in ultrafast enzymes that show little or no conformational changes.
    1. Biochemistry and Chemical Biology

    Mapping the functional landscape of the receptor binding domain of T7 bacteriophage by deep mutational scanning

    Phil Huss et al.
    An unbiased mutational screen decodes the molecular basis of phage receptor interactions, identifies key functional regions determining activity and host range, and demonstrates the potential for engineering therapeutic phages.
    1. Biochemistry and Chemical Biology
    2. Microbiology and Infectious Disease

    Dynamic interactions between the RNA chaperone Hfq, small regulatory RNAs, and mRNAs in live bacterial cells

    Seongjin Park et al.
    RNA chaperone Hfq dynamically binds various pools of cellular RNAs to execute different regulatory functions.
    1. Structural Biology and Molecular Biophysics

    Structural basis for human TRPC5 channel inhibition by two distinct inhibitors

    Kangcheng Song et al.
    The binding sites of two distinct TRPC5 inhibitors clemizole and HC-070 are revealed by cryo-EM.
    1. Cell Biology
    2. Neuroscience

    Genetic disruption of WASHC4 drives endo-lysosomal dysfunction and cognitive-movement impairments in mice and humans

    Jamie L Courtland et al.
    Cellular etiology of a human WASH complex mutation in mice reveals its specific roles in neuronal organelle trafficking and a surprising role in motor impairments.
    1. Chromosomes and Gene Expression
    2. Computational and Systems Biology

    Local genetic context shapes the function of a gene regulatory network

    Anna Nagy-Staron et al.
    The phenotype of a gene regulatory network depends both qualitatively and quantitatively on the local genetic context of its individual components and cannot necessarily be predicted solely from network's topology.