1,523 results found
    1. Biochemistry and Chemical Biology
    2. Microbiology and Infectious Disease

    NusG is an intrinsic transcription termination factor that stimulates motility and coordinates gene expression with NusA

    Zachary F Mandell et al.
    The general transcription elongation factor NusG functions as an intrinsic termination factor in Bacillus subtilis and together with NusA coordinates global gene expression including the motility regulon.
    1. Evolutionary Biology
    2. Physics of Living Systems

    Global epistasis emerges from a generic model of a complex trait

    Gautam Reddy, Michael M Desai
    Predictable patterns of fitness evolution observed in microbial evolution experiments can emerge generically as a consequence of widespread epistatic interactions between mutations.
    1. Cell Biology

    Glucose restriction drives spatial reorganization of mevalonate metabolism

    Sean Rogers et al.
    Genetic and biochemical analyses, coupled with fluorescence imaging, reveal that spatial compartmentalization of HMG-CoA Reductases at yeast ER-lysosome contacts modulates mevalonate pathway flux during glucose restriction, enabling metabolic adaptation.
    1. Biochemistry and Chemical Biology

    Virus Engineering: ORACLE reveals a bright future to fight bacteria

    Willow Coyote-Maestas, James S Fraser
    A new way to alter the genome of bacteriophages helps produce large libraries of variants, allowing these bacteria-killing viruses to be designed to target species harmful to human health.
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    1. Biochemistry and Chemical Biology

    Mapping the functional landscape of the receptor binding domain of T7 bacteriophage by deep mutational scanning

    Phil Huss et al.
    An unbiased mutational screen decodes the molecular basis of phage receptor interactions, identifies key functional regions determining activity and host range, and demonstrates the potential for engineering therapeutic phages.
    1. Cell Biology
    2. Developmental Biology

    The recycling endosome protein Rab25 coordinates collective cell movements in the zebrafish surface epithelium

    Patrick Morley Willoughby et al.
    Rab25a and Rab25b mutant embryos exhibit epithelial spreading delays during morphogenesis and are characterized by cytokinesis defects leading to cell fusions, heterogeneous epithelial cell sizes, and reduced cortical actomyosin contractility.
    1. Neuroscience

    Robust vestibular self-motion signals in macaque posterior cingulate region

    Bingyu Liu et al.
    Macaque posterior cingulate region carries vestibular dominant self-motion signals with plentiful temporal components that could be useful for process of path integration.
    1. Neuroscience

    Mechanism for differential recruitment of orbitostriatal transmission during actions and outcomes following chronic alcohol exposure

    Rafael Renteria et al.
    Chronic alcohol exposure results in a long-lasting, enhanced endocannabinoid signalling at orbitostriatal synapses that is expressed in a projection-, synapse-, and behaviorally computation-specific manner.
    1. Neuroscience

    Synaptotagmin-7 places dense-core vesicles at the cell membrane to promote Munc13-2- and Ca2+-dependent priming

    Bassam Tawfik et al.
    Synaptotagmin-7 acts synergistically with synaptotagmin-1 by placing vesicles close to the plasma membrane within reach of the SNARE/Munc13-complex, supporting their priming and setting the stage for fast and slow fusion.
    1. Evolutionary Biology
    2. Genetics and Genomics

    A common 1.6 mb Y-chromosomal inversion predisposes to subsequent deletions and severe spermatogenic failure in humans

    Pille Hallast et al.
    In addition to its academic merits, characterizing the genetic determinants of male (in)fertility and identifying clinically actionable genetic variants can lead to improved diagnosis or even treatment of such conditions.

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