Browse the search results

Page 2 of 154
    1. Cancer Biology
    2. Cell Biology

    Defective apoptotic cell contractility provokes sterile inflammation, leading to liver damage and tumour suppression

    Linda Julian et al.
    In the absence of ROCK1 activation by caspases, apoptotic cells don’t undergo typical morphological changes, leading to sterile inflammation in the liver that increases tissue damage and suppresses tumor formation.
    1. Cell Biology
    2. Medicine

    eNOS-induced vascular barrier disruption in retinopathy by c-Src activation and tyrosine phosphorylation of VE-cadherin

    Takeshi Ninchoji et al.
    Vascular leakage from pathological vessels in retinopathy aggravates the disease, but endothelial junction stability and barrier integrity can be restored by blocking formation of nitric oxide.
    1. Evolutionary Biology

    Evolution of the complex transcription network controlling biofilm formation in Candida species

    Eugenio Mancera et al.
    The transcription networks controlling biofilm formation in Candida species exhibit 'structural' similarities, but show gradual substitutions of transcription regulators and frequent changes in target genes.
    1. Neuroscience

    Learning excitatory-inhibitory neuronal assemblies in recurrent networks

    Owen Mackwood et al.
    The synaptic structure in mouse V1 is explained by a synergy of homeostatic plasticity in incoming and outgoing synapses of inhibitory interneurons, establishing a stimulus-specific balance of excitation and inhibition.
    1. Medicine
    2. Neuroscience

    PMCA-generated prions from the olfactory mucosa of patients with Fatal Familial Insomnia cause prion disease in mice

    Edoardo Bistaffa et al.
    The olfactory mucosa of patients with fatal familial insomnia contains traces of infectious prions, and their analyses could support the clinical diagnosis and elucidate disease-specific mechanisms.
    1. Neuroscience

    Optimal policy for attention-modulated decisions explains human fixation behavior

    Anthony I Jang et al.
    A normative decision-making model that incorporates an information-limiting attention bottleneck is able to qualitatively replicate human behavior and make novel predictions that are verified in data.
    1. Biochemistry and Chemical Biology
    2. Microbiology and Infectious Disease

    NusG is an intrinsic transcription termination factor that stimulates motility and coordinates gene expression with NusA

    Zachary F Mandell et al.
    The general transcription elongation factor NusG functions as an intrinsic termination factor in Bacillus subtilis and together with NusA coordinates global gene expression including the motility regulon.
    1. Evolutionary Biology
    2. Physics of Living Systems

    Global epistasis emerges from a generic model of a complex trait

    Gautam Reddy, Michael M Desai
    Predictable patterns of fitness evolution observed in microbial evolution experiments can emerge generically as a consequence of widespread epistatic interactions between mutations.
    1. Cell Biology

    Glucose restriction drives spatial reorganization of mevalonate metabolism

    Sean Rogers et al.
    Genetic and biochemical analyses, coupled with fluorescence imaging, reveal that spatial compartmentalization of HMG-CoA Reductases at yeast ER-lysosome contacts modulates mevalonate pathway flux during glucose restriction, enabling metabolic adaptation.
    1. Biochemistry and Chemical Biology

    Virus Engineering: ORACLE reveals a bright future to fight bacteria

    Willow Coyote-Maestas, James S Fraser
    A new way to alter the genome of bacteriophages helps produce large libraries of variants, allowing these bacteria-killing viruses to be designed to target species harmful to human health.
    Insight
    Available as:
    • HTML
    • PDF