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    1. Neuroscience

    Contrary neuronal recalibration in different multisensory cortical areas

    Fu Zeng, Adam Zaidel, Aihua Chen
    Single-unit recordings from cortical neurons in behaving macaque monkeys expose differential aspects of multisensory plasticity across different multisensory areas during visual–vestibular recalibration.
    1. Immunology and Inflammation
    2. Medicine

    Transcriptome network analysis implicates CX3CR1-positive type 3 dendritic cells in non-infectious uveitis

    Sanne Hiddingh, Aridaman Pandit ... Jonas JW Kuiper
    CX3CR1-positive dendritic cells are altered in patients with non-infectious uveitis.
    1. Biochemistry and Chemical Biology
    2. Microbiology and Infectious Disease

    Hydrogen sulfide blocks HIV rebound by maintaining mitochondrial bioenergetics and redox homeostasis

    Virender Kumar Pal, Ragini Agrawal ... Amit Singh
    A gaseous signaling molecule hydrogen sulfide stimulates mitochondrial bioenergetics, maintains glutathione redox poise, and suppresses ROS to subvert viral rebound in latently infected CD4+ T cells from HIV subjects.
    1. Neuroscience

    Ca2+ channel and active zone protein abundance intersects with input-specific synapse organization to shape functional synaptic diversity

    Audrey T Medeiros, Scott J Gratz ... Kate M O'Connor-Giles
    In vivo analysis of endogenously tagged Ca2+ channel subunits reveals unexpected differences in subunit composition and synapse-specific relationships between channel abundance and synaptic strength.
    1. Neuroscience

    Inhibitory CCK+ basket synapse defects in mouse models of dystroglycanopathy

    Jennifer N Jahncke, Daniel S Miller ... Kevin M Wright
    Loss of functional dystroglycan disrupts the formation and function of CCK+/CB1R+ inhibitory synapses in hippocampal CA1, resulting in reduced seizure thresholds in mouse models of dystroglycanopathy.
    1. Stem Cells and Regenerative Medicine
    2. Chromosomes and Gene Expression

    Polycomb enables primitive endoderm lineage priming in embryonic stem cells

    Robert S Illingworth, Jurriaan J Hölzenspies ... Joshua M Brickman
    Polycomb enables lineage priming in mouse embryonic stem cells by establishing a barrier to commitment.
    1. Structural Biology and Molecular Biophysics

    Mechanism of pharmacochaperoning in a mammalian KATP channel revealed by cryo-EM

    Gregory M Martin, Min Woo Sung ... Show-Ling Shyng
    Diverse KATP channel inhibitors occupy a common binding pocket and stabilize an interaction between Kir6.2 and SUR1 to allosterically control gating and promote the assembly and trafficking of nascent channels.
    1. Neuroscience

    Robust effects of corticothalamic feedback and behavioral state on movie responses in mouse dLGN

    Martin A Spacek, Davide Crombie ... Laura Busse
    Electrophysiology and optogenetic circuit manipulation in the mouse visual system reveal that corticothalamic feedback and behavioral state both have robust modulatory, yet largely independent influences on thalamic responses to naturalistic movies.
    1. Microbiology and Infectious Disease

    GWAS and functional studies suggest a role for altered DNA repair in the evolution of drug resistance in Mycobacterium tuberculosis

    Saba Naz, Kumar Paritosh ... Vinay Kumar Nandicoori
    Genome sequence analysis of Mycobacterium tuberculosis clinical isolates and subsequent validation in laboratory and animal infection models identify previously unrecognized genetic mutations in DNA repair genes that contribute to the development of drug resistance.
    1. Structural Biology and Molecular Biophysics

    Calcium-driven regulation of voltage-sensing domains in BK channels

    Yenisleidy Lorenzo-Ceballos, Willy Carrasquel-Ursulaez ... Ramon Latorre
    Gating currents analysis at different Ca2+ concentrations of BK channels reveals a strong allosteric coupling between Ca2+- and voltage-sensing modules via equivalent contributions exerted by the RCK1 and RCK2 Ca2+-sites.