216 results found
    1. Neuroscience

    Neuropathic Pain: The pros and cons of degeneracy

    Jean-Marc Goaillard, Martial A Dufour
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    1. Neuroscience

    Criticality and degeneracy in injury-induced changes in primary afferent excitability and the implications for neuropathic pain

    Stéphanie Ratté et al.
    No single molecular change is uniquely necessary to cause neuropathic changes in primary afferent excitability; multiple different changes are sufficient.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Viral GPCR US28 can signal in response to chemokine agonists of nearly unlimited structural degeneracy

    Timothy F Miles et al.
    Numerous chemokine variants bearing no sequence resemblance elicit similar signaling behavior from the viral GPCR US28, suggesting a mechanism for receptor activation that accommodates extensive ligand degeneracy.
    1. Cell Biology
    2. Physics of Living Systems

    Morphogenetic degeneracies in the actomyosin cortex

    Sundar Ram Naganathan et al.
    Distinct molecular functions contribute to the same material property at larger scales leading to degenerate functionality.
    1. Developmental Biology

    The Natural History of Model Organisms: An organismal perspective on C. intestinalis development, origins and diversification

    Matthew J Kourakis, William C Smith
    The life cycle and morphology of the sea squirt Ciona intestinalis shed light on vertebrate evolution.
    1. Neuroscience

    Memory: Forget me not

    Richard GM Morris
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    1. Cell Biology
    2. Human Biology and Medicine

    Muscle Contraction: Too much of a good thing

    H Lee Sweeney
    A mutation that causes heart disease in humans increases the number of active myosin heads during contraction in the muscles of fruit flies, leading to the progressive dysfunction of the flight muscles and heart tube.
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    1. Chromosomes and Gene Expression

    Cooperative interactions enable singular olfactory receptor expression in mouse olfactory neurons

    Kevin Monahan et al.
    Biochemical and genetic experiments show that Ebf and Lhx2 cooperate to specify olfactory receptor enhancers, which cooperate to drive olfactory receptor expression.
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    wtf genes are prolific dual poison-antidote meiotic drivers

    Nicole L Nuckolls et al.
    Selfish wtf meiotic drive genes use overlapping transcripts to encode both a trans-acting poison to kill gametes that do not inherit the gene and a gamete-autonomous antidote to specifically rescue the gametes that do.
    1. Neuroscience

    Early intrinsic hyperexcitability does not contribute to motoneuron degeneration in amyotrophic lateral sclerosis

    Félix Leroy et al.
    Contrary to a long-standing hypothesis, the neuronal death that leads to muscle wastage in amyotrophic lateral sclerosis does not result from overactivity of those neurons during development.

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