2,687 results found
    1. Chromosomes and Gene Expression
    2. Cell Biology

    Aging, Geroscience and Longevity: A Special Issue

    Edited by Matt Kaeberlein et al.
    eLife is pleased to present a Special Issue to highlight recent advances in the mechanistic understanding of aging and interventions that extend longevity.
  1. Event Report: Aging, Geroscience and Longevity Symposium

    Catch up on our online symposium in which eLife authors showcased their research from the upcoming Aging, Geroscience and Longevity Special Issue.
  2. Event Report: A second Aging, Geroscience and Longevity Symposium

    Catch up on our second online symposium in which eLife authors showcased their research published in the Aging, Geroscience and Longevity Special Issue.
  3. Image of interviewee Phyllis Kalele

    Equity, Diversity and Inclusion: GenderInSITE

    Phyllis Kalele describes how family responsibilities, a lack of mentorship, and ‘old boys’ clubs’ are some of the challenges faced by women working in science across the African continent.
    1. Biochemistry and Chemical Biology

    Webinar Report: Unpuzzling proteins

    Ivan Dikic, eLife Senior Editor, and his guests discussed the most exciting discoveries and challenges at the forefront of protein biochemistry.
  4. Controlling traffic: an interview with Ramanath Hegde

    Ramanath Hegde is a Postdoctoral Fellow at the Institute of Protein Biochemistry in Naples, Italy, where he investigates ways of preventing cells from destroying mutant proteins. He maintains his original interest in engineering through a variety of hobbies, including carpentry.
    1. Cell Biology
    2. Medicine

    Remodeling of whole-body lipid metabolism and a diabetic-like phenotype caused by loss of CDK1 and hepatocyte division

    Jin Rong Ow et al.
    Loss of hepatic Cdk1 leads to oxidative stress, increased fatty acids in blood, and hyperinsulinemia, which resulted in insulin resistance and hepatic steatosis, similar as in diabetes.
    1. Chromosomes and Gene Expression
    2. Developmental Biology

    SMC5/6 is required for replication fork stability and faithful chromosome segregation during neurogenesis

    Alisa Atkins et al.
    The structural maintenance of chromosomes complex, SMC5/6, is crucial for brain development and function as it ensures proficient DNA replication in neural progenitor cells prior to chromosome segregation.
    1. Neuroscience

    Rapid computations of spectrotemporal prediction error support perception of degraded speech

    Ediz Sohoglu, Matthew H Davis
    Analysis of speech acoustics and human brain activity reveals the neural computations by which listeners combine speech input with prior expectations.
    1. Biochemistry and Chemical Biology

    Bacterial OTU deubiquitinases regulate substrate ubiquitination upon Legionella infection

    Donghyuk Shin et al.
    A novel class of bacterial OTU deubiquitinases provides insights on the distinct roles of bacterial deubiquitinases in host–pathogen interactions.

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