5,438 results found
    1. Cell Biology
    2. Developmental Biology

    zGrad is a nanobody-based degron system that inactivates proteins in zebrafish

    Naoya Yamaguchi et al.
    The F-box/anti-GFP nanobody fusion protein zGrad depletes GFP-tagged proteins with spatial and temporal control in zebrafish.
    1. Stem Cells and Regenerative Medicine

    Mouse embryonic stem cells can differentiate via multiple paths to the same state

    James Alexander Briggs et al.
    Single cell RNA sequencing reveals that mouse embryonic stem cells can be differentiated into the same terminal motor neuron state via distinct differentiation paths, one of which includes a surprising intermediate state not found in embryos.
    1. Developmental Biology

    Neuron hemilineages provide the functional ground plan for the Drosophila ventral nervous system

    Robin M Harris et al.
    Hemilineages link neuronal stem cells to behavioral functions by providing a conserved ground plan of neuronal types that evolution then uses to sculpt different types of walking and flight behaviors.
    1. Stem Cells and Regenerative Medicine

    Systemic and local cues drive neural stem cell niche remodelling during neurogenesis in Drosophila

    Pauline Spéder, Andrea H Brand
    Cross talk between neural stem cells and their glial niche enables the niche to adapt to the evolving needs of the stem cells throughout development.
    1. Stem Cells and Regenerative Medicine
    2. Neuroscience

    Imaging-based chemical screening reveals activity-dependent neural differentiation of pluripotent stem cells

    Yaping Sun et al.
    A chemical screen reveals that a compound used to treat a parasitic disease can trigger pluripotent stem cells to become neurons, uncovering a novel mechanism behind neuronal development.
    1. Neuroscience

    Combinatorial programming of human neuronal progenitors using magnetically-guided stoichiometric mRNA delivery

    Sayyed M Azimi et al.
    A technology allows rapid screening of vast numbers of transcriptional factor combinatorials on stem cell programming.
    1. Neuroscience

    Optimal compensation for neuron loss

    David GT Barrett et al.
    Spiking networks compensate the loss of neurons instantaneously, when restoration of excitatory/inhibitory balance becomes equivalent to restoration of functionality.
    1. Developmental Biology
    2. Chromosomes and Gene Expression

    Core promoter factor TAF9B regulates neuronal gene expression

    Francisco J Herrera et al.
    An orphan TBP-associated factor, TAF9B, works in conjunction with the histone acetyl-transferase PCAF as transcriptional co-regulators of neuronal differentiation.
    1. Stem Cells and Regenerative Medicine

    Chemical modulation of transcriptionally enriched signaling pathways to optimize the conversion of fibroblasts into neurons

    Joseph Herdy et al.
    An unbiased RNAseq based strategy to identify targetable pathways and a streamlined lentiviral system provide a state of the art advance on direct fibroblast to neuron conversion.

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