25 results found
    1. Developmental Biology
    2. Ecology

    Fish larval recruitment to reefs is a thyroid hormone-mediated metamorphosis sensitive to the pesticide chlorpyrifos

    Guillaume Holzer, Marc Besson ... Vincent Laudet
    Coral reef fish larval recruitment is a metamorphosis that can be disturbed by reef pollutants, as it is under the influence of the environment through the direct control of thyroid hormone signaling.
    1. Developmental Biology

    Transient hypothyroidism favors oligodendrocyte generation providing functional remyelination in the adult mouse brain

    Sylvie Remaud, Fernando C Ortiz ... Barbara Demeneix
    Production of remyelinating subventricular zone oligodendrocyte progenitors is stimulated by transient abrogation of thyroid hormone signalling in the adult neural stem cell niche.
    1. Medicine

    Axonal T3 uptake and transport can trigger thyroid hormone signaling in the brain

    Federico Salas-Lucia, Csaba Fekete ... Antonio C Bianco
    T3 is taken up by axonal termini and is retrogradely transported into endosomal vesicles to the cell nucleus, where it regulates gene expression.
    1. Computational and Systems Biology

    Rewiring of liver diurnal transcriptome rhythms by triiodothyronine (T3) supplementation

    Leonardo Vinicius Monteiro de Assis, Lisbeth Harder ... Henrik Oster
    High triiodothyronine levels lead to a broad rewiring of the liver transcriptome, which mostly occurs downstream of the liver clock machinery itself, thus suggesting that daytime critically affects thyroid hormone action in the liver.
    1. Neuroscience

    Noradrenaline release from the locus coeruleus shapes stress-induced hippocampal gene expression

    Mattia Privitera, Lukas M von Ziegler ... Johannes Bohacek
    Targeted manipulation of the locus coeruleus noradrenaline circuitry combined with extensive transcriptomic analyses in the mouse hippocampus reveal a unique set of noradrenaline-dependent, stress-related genes and point to astrocytic engagement.
    1. Neuroscience

    Early life stressful experiences escalate aggressive behavior in adulthood via changes in transthyretin expression and function

    Rohit Singh Rawat, Aksheev Bhambri ... Arpita Konar
    Hypothalamic TTR as a novel molecular player of stress-induced long-term impact on behavior.
    1. Computational and Systems Biology

    Metabolic network percolation quantifies biosynthetic capabilities across the human oral microbiome

    David B Bernstein, Floyd E Dewhirst, Daniel Segrè
    A novel metabolic network analysis method enables large-scale computational predictions of biosynthetic capabilities across the human oral microbiome, revealing a unique cluster of fastidious microorganisms and potential metabolic interdependencies.
    1. Neuroscience

    FSHβ links photoperiodic signaling to seasonal reproduction in Japanese quail

    Gaurav Majumdar, Timothy A Liddle ... Tyler Stevenson
    Molecular analyses reveal the neuroendocrine control of seasonal life-history transitions in birds.
    1. Genetics and Genomics

    Brown adipocytes local response to thyroid hormone is required for adaptive thermogenesis in adult male mice

    Yanis Zekri, Romain Guyot ... Karine Gauthier
    T3 regulates BAT thermogenesis by controlling the expression of genes involved in the management of metabolic fuels as well as tissue plasticity.
    1. Cell Biology
    2. Medicine

    Quantitative mapping of human hair greying and reversal in relation to life stress

    Ayelet M Rosenberg, Shannon Rausser ... Martin Picard
    A method to profile hair pigmentation patterns establishes a new approach for psychobiological studies and links metabolic changes to greying in humans.

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