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Transcriptomic analyses of Malabar grouper show pathways known to be involved in metamorphosis are also upregulated at an early stage of larval development, suggesting an additional function during early development.

The catalytic activity of SARM1, a key promoter of neuronal degeneration, is activated by >2000-fold by a phase transition.

PSTPIP2 reduced IL-19 secretion by inhibiting activation of the NF-κB pathway in renal tubular epithelial cells (RTECs), reducing the generation of neutrophil extracellular trap, which can participate in both aristolochic acid I-induced renal injury and apoptosis in RTECs.

The preoptic area (POA) regulates distinct metabolic adaptations, via leptin-dependent (fasting-induced hypometabolism and high-fat-diet-induced hypermetabolism), or leptin-independent mechanisms (temperature induced metabolic changes) and thus significantly contributes to body weight homeostasis.

Comparative transcriptome analyses of human placenta reveal regulatory divergence between native highlanders and lowland immigrants living at high altitude, and a sex-biased pattern of genetic adaptation.

Dietary selenium supplementation confers to mice all of the short-term healthspan benefits of the longevity-promoting intervention methionine restriction, and thus may represent a method to promote healthy aging in mammals.

Diurnal variation loss of pineal allopregnanolone synthesis by light-at-night induces pituitary adenylate cyclase-activating polypeptide (PACAP) reduction and transcriptional PACAP repression in the cerebellum, with subsequent Purkinje cell death.

The principle underlying the appearance of the growth plate, an organ responsible for longitudinal growth, has implications for various cartilage pathologies including growth abnormalities in children, trauma and osteoarthritis.

Single-cell RNA-sequencing, spatial genomics, and histological analyses reveal that cold-induced brown adipose neogenesis is a complex adaptive response to elevated metabolic demand involving dynamic interactions between recruited immune cells and a subpopulation of poised adipocyte progenitors.