82 results found
    1. Cell Biology
    2. Plant Biology

    Natural variation reveals that intracellular distribution of ELF3 protein is associated with function in the circadian clock

    Muhammad Usman Anwer, Eleni Boikoglou ... Seth Jon Davis
    In Arabidopsis, a natural variant of the ELF3 protein, which originated in Central Asia, is less likely to accumulate in the nucleus, and causes the circadian clock to run faster and be less responsive to environmental cues.
    1. Neuroscience

    Homeostatic reinforcement learning for integrating reward collection and physiological stability

    Mehdi Keramati, Boris Gutkin
    A mathematical model built around the assumption that the desire to maintain internal homeostasis drives the behavior of animals, by affecting their learning processes, can explain many real-world behaviors, including some that might otherwise appear irrational.
    1. Computational and Systems Biology
    2. Neuroscience

    Attention stabilizes the shared gain of V4 populations

    Neil C Rabinowitz, Robbe L Goris ... Eero P Simoncelli
    Populations of neurons in the macaque visual cortex are subject to shared fluctuations in gain; these signals exhibit anatomical and functional structure, and their variability is diminished under attention.
    1. Computational and Systems Biology
    2. Physics of Living Systems

    Persistence, period and precision of autonomous cellular oscillators from the zebrafish segmentation clock

    Alexis B Webb, Iván M Lengyel ... Andrew C Oates
    Time-lapse recording and theoretical analysis of individual cells isolated from the zebrafish segmentation clock reveal that they behave as self-sustained, autonomous oscillators with distinctive noisy dynamics.
    1. Neuroscience

    A common mechanism underlies changes of mind about decisions and confidence

    Ronald van den Berg, Kavitha Anandalingam ... Daniel M Wolpert
    Initial confidence and choice in a decision, and their potential revision, arise from a common mechanism that challenges models that claim confidence and decision processes are dissociated.
    1. Neuroscience

    The modulation of savouring by prediction error and its effects on choice

    Kiyohito Iigaya, Giles W Story ... Peter Dayan
    The anticipation of rewards turns out to have its own hedonic value, on top of that of the reward itself; a wide range of behavioral and neurophysiological data suggest that this anticipation is boosted by prediction errors.
    1. Neuroscience

    Uncertainty leads to persistent effects on reach representations in dorsal premotor cortex

    Brian M Dekleva, Pavan Ramkumar ... Lee E Miller
    When Rhesus monkeys plan reaching movements of which they are not fully confident, a particular area of the brain represents both the chosen action as well as alternate movements, perhaps as an aid for error correction or learning.
    1. Neuroscience

    Subthalamic, not striatal, activity correlates with basal ganglia downstream activity in normal and parkinsonian monkeys

    Marc Deffains, Liliya Iskhakova ... Hagai Bergman
    The spiking activity of the subthalamic nucleus, rather than the activity of striatal projection neurons, orchestrates basal ganglia downstream activity and output commands in health and Parkinson’s disease.
    1. Neuroscience
    2. Computational and Systems Biology

    A specific role for serotonin in overcoming effort cost

    Florent Meyniel, Guy M Goodwin ... Raphaël Gaillard
    A selective reuptake inhibitor shows a beneficial effect in healthy humans during an effort-benefit tradeoff task, mediated at the computational level by a specific alleviation of effort cost.
    1. Neuroscience

    Perceptually relevant remapping of human somatotopy in 24 hours

    James Kolasinski, Tamar R Makin ... Heidi Johansen-Berg
    A combination of 7 tesla fMRI and psychophysics revealed the reorganisation of the human somatosensory cortex and changes in tactile perceptual abilities after just 24 hours of altered hand use.

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