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    1. Neuroscience

    Noradrenaline release from the locus coeruleus shapes stress-induced hippocampal gene expression

    Mattia Privitera, Lukas M von Ziegler ... Johannes Bohacek
    Targeted manipulation of the locus coeruleus noradrenaline circuitry combined with extensive transcriptomic analyses in the mouse hippocampus reveal a unique set of noradrenaline-dependent, stress-related genes and point to astrocytic engagement.
    1. Neuroscience

    Resource-rational account of sequential effects in human prediction

    Arthur Prat-Carrabin, Florent Meyniel, Rava Azeredo da Silveira
    A proposed model of optimal inference under cognitive costs accounts for human sequential effects, including subtle patterns of attractive and repulsive influence of past observations, in a binary prediction task across a wide range of stimulus conditions.
    1. Neuroscience

    Suggestion of creatine as a new neurotransmitter by approaches ranging from chemical analysis and biochemistry to electrophysiology

    Xiling Bian, Jiemin Zhu ... Yi Rao
    While neurotransmitters were discovered decades ago, evidence suggests that more transmitters are to be discovered using the presented approaches.
    1. Neuroscience

    On the computational principles underlying human exploration

    Lior Fox, Ohad Dan, Yonatan Loewenstein
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Incomplete
    1. Computational and Systems Biology
    2. Developmental Biology

    How enhancers regulate wavelike gene expression patterns

    Christine Mau, Heike Rudolf ... Ezzat El-Sherif
    An experimental and computational system has been developed to investigate how wavelike gene expression patterns are generated during embryonic development.
    1. Neuroscience

    Neural dynamics underlying self-control in the primate subthalamic nucleus

    Benjamin Pasquereau, Robert S Turner
    Cost–benefit integration between the desirability of the expected reward and the imposed delay to delivery is supported by STN signals that dynamically combined both reward-related attributes to form a single integrated value estimate along an antero-posterior axis in this nucleus.
    1. Computational and Systems Biology

    Learning predictive cognitive maps with spiking neurons during behavior and replays

    Jacopo Bono, Sara Zannone ... Claudia Clopath
    Predictive cognitive maps can be learned during behavior and replays using in spiking neurons.
    1. Neuroscience

    Rapid learning of predictive maps with STDP and theta phase precession

    Tom M George, William de Cothi ... Caswell Barry
    A close approximation to the successor representation is learnt by a simple spike-time-dependent learning rule between cells undergoing theta phase precession.
    1. Neuroscience

    A process model account of the role of dopamine in intertemporal choice

    Alexander Soutschek, Philippe N Tobler
    Drift diffusion models suggest that dopamine affects dissociable components of the decision process in intertemporal choice, underlining the importance of analyzing the effects of neural interventions with process models.
    1. Computational and Systems Biology
    2. Neuroscience

    Temporal derivative computation in the dorsal raphe network revealed by an experimentally driven augmented integrate-and-fire modeling framework

    Emerson F Harkin, Michael B Lynn ... Jean-Claude Béïque
    A new type of biologically constrained spiking neural network model applied to the dorsal raphe nucleus shows that the output of the serotonin system reflects not just its raw input, but mainly how quickly its input changes over time.