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    1. Neuroscience

    Non-rapid eye movement sleep and wake neurophysiology in schizophrenia

    Nataliia Kozhemiako, Jun Wang ... Jen Q Pan
    Multiple non-redundant features of non-rapid eye movement sleep are altered in schizophrenia and largely independent of waking electrophysiological abnormalities, supporting the promise of neuropsychiatric disease biomarkers based on a precise dissection of the sleep.
    1. Genetics and Genomics
    2. Plant Biology

    Principles of mRNA targeting via the Arabidopsis m6A-binding protein ECT2

    Laura Arribas-Hernández, Sarah Rennie ... Peter Brodersen
    The Arabidopsis N6-methyladenosine (m6A)-binding protein ECT2 binds to m6A in the canonical RR[m6A]CH motif, not a plant-specific motif as previously thought, and its intrinsically disordered region contributes to mRNA binding via contacts with U-rich motifs.
    1. Ecology

    Climate-driven deoxygenation elevates fishing vulnerability for the ocean's widest ranging shark

    Marisa Vedor, Nuno Queiroz ... David W Sims
    Habitats of satellite-tracked blue sharks were shifted surfaceward by an oxygen minimum zone (OMZ) at depth thereby increasing their susceptibility to capture by longline fishing focused above the OMZ.
    1. Plant Biology

    A cis-carotene derived apocarotenoid regulates etioplast and chloroplast development

    Christopher I Cazzonelli, Xin Hou ... Barry J Pogson
    Carotenoids are not just required as core components for plastid biogenesis, they can be cleaved into an apocarotenoid signal that regulates etioplast and chloroplast development during extended periods of darkness.
    1. Ecology

    Diversity-decomposition relationships in forests worldwide

    Liang Kou, Lei Jiang ... Huimin Wang
    Carbon dynamics and the relative availability of key nutrients during litter decomposition are modified by changing biodiversity in the Earth’s forests.
    1. Cancer Biology

    NF1 regulates mesenchymal glioblastoma plasticity and aggressiveness through the AP-1 transcription factor FOSL1

    Carolina Marques, Thomas Unterkircher ... Massimo Squatrito
    Neurofibromatosis type 1 gene (NF1) signaling is causally linked to the acquisition of a mesenchymal gene expression program in gliomas through the regulation of the AP-1 transcription factor FOSL1.
    1. Stem Cells and Regenerative Medicine

    Skeletal dysplasia-causing TRPV4 mutations suppress the hypertrophic differentiation of human iPSC-derived chondrocytes

    Amanda R Dicks, Grigory I Maksaev ... Farshid Guilak
    Chondrocytes derived from induced pluripotent stem cells with the dysplasia-causing TRPV4 mutations, V620I and T89I mutation, were resistant to BMP4-induced hypertrophy, suggesting a mechanism underlying the effects of TRPV4 dysfunction on the severity of skeletal dysplasia.
    1. Medicine

    Estimating bone marrow adiposity from head MRI and identifying its genetic architecture

    Tobias Kaufmann, Pål Marius Bjørnstad ... Timothy Hughes
    Not revised
    Reviewed Preprint v1
    • Important
    • Solid
    1. Developmental Biology
    2. Plant Biology

    Cell type boundaries organize plant development

    Monica Pia Caggiano, Xiulian Yu ... Marcus G Heisler
    Leaf position, shape and orientation are pre-patterned by cell type boundaries in the shoot meristem.
    1. Cancer Biology
    2. Epidemiology and Global Health

    Effect of cancer on outcome of COVID-19 patients: a systematic review and meta-analysis of studies of unvaccinated patients

    Giulia Di Felice, Giovanni Visci ... Paolo Boffetta
    A twofold increased risk of adverse outcomes (mortality, ICU admission, and severity of COVID-19) has been demonstrated in unvaccinated COVID-19 patients with cancer compared to COVID-19 patients without cancer.