Signalling that maintains rapid translation elongation in KRAS-mutant colorectal cancer models can be targeted by mutation of the ribosomal protein RPL24 to suppress tumour proliferation.

Genome-wide analyses reveal how tumor-associated mutations of the Fbw7 ubiquitin ligase impact oncogenic transcription factors and gene expression.

A tumor-specific regulatory region has been identified upstream of the Myc oncogene.

Gene copy number provides more prognostic information than gene mutation status in cancer.

Proteomics and functional genomics coupled to an antibody discovery pipeline revealed the influence of oncogenic RAS signaling on the cell-surface proteome and resulted in the discovery of potential therapeutic targets for RAS-driven cancers.

A comprehensive catalogue of somatic mutations accumulating in MMR-deficient tumors highlights their relevance in the context of human genetic evolution, for the diagnosis of microsatellite instability and the provision of targeted treatment options.

miR-31 drives proliferation of intestinal stem cells, and protects intestinal stem cells against apoptosis both during homeostasis and regeneration in response to ionizing radiation injury, and promotes intestinal tumorigenesis through regulation of multiple signaling pathways.

Structure-based designed chalcone and pyrazoline derivatives inhibited the ELF3-MED23 protein-protein interaction, leading to HER2 downregulation and retardation of tumor growth in HER2-positive gastric cancer.

Deficiencies of several DNA damage response genes can be predicted by their association with genome-wide mutation patterns.

In contrast with earlier conclusions, negative selection has a major role in cancer evolution.