Harmful genetic variants at mendelian disease genes slow down adaptation, by interfering with the spread of adaptive variants in a population.

Population genetics in turquoise killifish wild populations reveals how small population size and genetic drift determine the accumulation of deleterious gene variants leading to short lifespan.

Deleterious mutations slow down flu's antigenic evolution, make it more punctuated in nature, and reduce the virus's genetic diversity.

The longer duration of seasonal influenza virus infection in young children may provide opportunities for within-host evolution as a result of maintenance of genetic diversity through mutation-selection balance.

An in-depth metagenomic analysis of possibly the most abundant and widespread microbial lineage in the surface ocean teases apart evolutionary processes that maintain its genomic heterogeneity and biogeography.

Distinct selective landscapes in mosquito and human cells shape dengue virus genetic diversity and highlight mechanisms of host adaptation in arboviruses.

In the context of susceptibility to severe COVID-19, the observations of a study provide the basis for a personalized interferon-based therapy in patients with rare TLR7 variants.

Synonymous mutations can have highly variable fitness effects stemming from changes in transcription, some of which contribute to adaptation.

Cell division by meiosis during sperm production depends on expression of an RNA-binding protein that prevents abnormal RNA-processing pathways.

The impact of changing gene expression noise on fitness reveals beneficial or deleterious effects in a stable environment depending how close the average expression level is to the fitness optimum.