Analysis of a variant without lysine in the intracellular domain reveals a ubiquitylation-independent signalling activity of the DSL ligand Delta and novel functions of the Neuralized and Mindbomb1 E3-ligases during Notch signalling.
Cytonemes mediate, and are essential for, Wingless signaling from the Drosophila wing disc to disc-associated myoblasts and for Delta-Notch signaling from these myoblasts to the dorsal air sac primordium.
Notch ligands from the Delta and Jagged families have distinct roles in epithelial progenitor cell fate of extrapulmonary and intrapulmonary airways and differentially restrict expansion of the neuroendocrine microenvironment.
Cells of the xanthophore lineage form projections that allow them to communicate with other pigment cells during adult pigment pattern formation in zebrafish, but not in the closely-related pearl danio.
Multiphoton live-imaging illuminates the dynamic underpinnings of how different types of progenitor cells migrate and interact to robustly build the mammalian Dentate Gyrus neural circuitry and new outer neurogenic niche.
The Notch signaling pathway has a central role in the development of the nervous system, and also in the establishment of networks of connections in the adult brain
The analysis of injury-reactivated tectal radial glia in zebrafish reveals a stochastic cell-cycle entry and cell-state-dependent regulation of the balance between neurogenesis and gliogenesis.
Modeling adult muscle homeostasis, maintenance and repair will now be possible in Drosophila with the discovery of satellite cells equivalents in flight muscles.
A model of signalling pathways interacting with proneural gene expression explains the sequential patterning of the largest visual processing centre in the developing Drosophila brain.
