145 results found
    1. Cell Biology
    2. Neuroscience

    Dual function of the PI3K-Akt-mTORC1 axis in myelination of the peripheral nervous system

    Gianluca Figlia et al.
    High PI3K-Akt-mTORC1 activity inhibits Schwann cell differentiation, while after onset of myelination, residual PI3K-Akt-mTORC1 activity promotes myelin growth.
    1. Neuroscience

    CNS myelination and remyelination depend on fatty acid synthesis by oligodendrocytes

    Penelope Dimas et al.
    Endogenous synthesis of fatty acids by oligodendrocytes is essential for development and repair in the central nervous system.
    1. Neuroscience

    Prolonging the integrated stress response enhances CNS remyelination in an inflammatory environment

    Yanan Chen et al.
    Oligodendrocytes with an enhanced ability to withstand cytotoxic stress display an increased capacity to remyelinate demyelination lesions of the CNS in the presence of an inflammatory environment.
    1. Neuroscience

    YAP/TAZ initiate and maintain Schwann cell myelination

    Matthew Grove et al.
    Yap and Taz regulate proliferation and differentiation of Schwann cells, driving radial sorting, myelination and myelin maintenance of peripheral nerves.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    The Ormdl genes regulate the sphingolipid synthesis pathway to ensure proper myelination and neurologic function in mice

    Benjamin A Clarke et al.
    The ORMDL proteins function to restrain the de novo sphingolipid biosynthetic pathway during myelination, when there is a high demand for sphingolipids to prevent excessive accumulation of metabolic intermediates.
    1. Developmental Biology
    2. Neuroscience

    Identification of compounds that rescue otic and myelination defects in the zebrafish adgrg6 (gpr126) mutant

    Elvira Diamantopoulou et al.
    Results of a zebrafish whole-animal chemical screen for compounds that can rescue ear and myelination defects in an adhesion GPCR (Adgrg6/Gpr126) mutant.
    1. Neuroscience

    Accelerated remyelination during inflammatory demyelination prevents axonal loss and improves functional recovery

    Feng Mei et al.
    Uncoupling the immunological response and degenerative processes from possible repair demonstrates that remyelination prevents axonal loss after inflammatory demyelination.
    1. Neuroscience

    Microglial SIRPα regulates the emergence of CD11c+ microglia and demyelination damage in white matter

    Miho Sato-Hashimoto et al.
    A cell-cell contact between microglial SIRPα and CD47 on neighboring cells is a critical module for phase conversion of microglia in the brain white matter and controls demyelination.
    1. Neuroscience

    Circulating transforming growth factor-β1 facilitates remyelination in the adult central nervous system

    Machika Hamaguchi et al.
    Although central nervous system (CNS) regeneration has been considered to be controlled by CNS microenvironment, CNS injury causes leading to leakage of circulating factors into CNS, which promotes CNS regeneration.
    1. Neuroscience

    Microglial transglutaminase-2 drives myelination and myelin repair via GPR56/ADGRG1 in oligodendrocyte precursor cells

    Stefanie Giera et al.
    A combined approach of unbiased proteomics, biochemistry, genetics, and transgenic animal models reveals that GPR56/ADGRG1 regulates myelin formation and repair by interacting with its microglial-derived ligand transglutaminase 2.

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