56 results found
    1. Neuroscience

    YAP/TAZ initiate and maintain Schwann cell myelination

    Matthew Grove et al.
    Yap and Taz regulate proliferation and differentiation of Schwann cells, driving radial sorting, myelination and myelin maintenance of peripheral nerves.
    1. Cell Biology
    2. Neuroscience

    Dual function of the PI3K-Akt-mTORC1 axis in myelination of the peripheral nervous system

    Gianluca Figlia et al.
    High PI3K-Akt-mTORC1 activity inhibits Schwann cell differentiation, while after onset of myelination, residual PI3K-Akt-mTORC1 activity promotes myelin growth.
    1. Neuroscience

    Accelerated remyelination during inflammatory demyelination prevents axonal loss and improves functional recovery

    Feng Mei et al.
    Uncoupling the immunological response and degenerative processes from possible repair demonstrates that remyelination prevents axonal loss after inflammatory demyelination.
    1. Neuroscience

    Microglial transglutaminase-2 drives myelination and myelin repair via GPR56/ADGRG1 in oligodendrocyte precursor cells

    Stefanie Giera et al.
    A combined approach of unbiased proteomics, biochemistry, genetics, and transgenic animal models reveals that GPR56/ADGRG1 regulates myelin formation and repair by interacting with its microglial-derived ligand transglutaminase 2.
    1. Neuroscience

    An automated high-resolution in vivo screen in zebrafish to identify chemical regulators of myelination

    Jason J Early et al.
    A fully automated high-resolution in vivo screening platform for zebrafish was implemented and used to identify novel compounds that regulate oligodendrocyte lineage progression.
    1. Developmental Biology
    2. Neuroscience

    Signalling through AMPA receptors on oligodendrocyte precursors promotes myelination by enhancing oligodendrocyte survival

    Eleni Kougioumtzidou et al.
    Electrically active axons in white matter stimulate their own myelination by releasing glutamate, which signals through AMPA-type glutamate receptors on nearby oligodendrocyte precursors and newly-differentiating oligodendrocytes, enhancing their survival and hence their ability to myelinate.
    1. Developmental Biology

    Transient hypothyroidism favors oligodendrocyte generation providing functional remyelination in the adult mouse brain

    Sylvie Remaud et al.
    Production of remyelinating subventricular zone oligodendrocyte progenitors is stimulated by transient abrogation of thyroid hormone signalling in the adult neural stem cell niche.
    1. Neuroscience

    Mild myelin disruption elicits early alteration in behavior and proliferation in the subventricular zone

    Elizabeth A Gould et al.
    Mild myelin disruption leads to early axonal pathology, a novel pathological response in neural stem cells, regionally increased oligodendrocytes and altered behavior.
    1. Neuroscience

    PTEN negatively regulates the cell lineage progression from NG2+ glial progenitor to oligodendrocyte via mTOR-independent signaling

    Estibaliz González-Fernández et al.
    OPC-specific genetic inhibition of Akt upstream and downstream molecules in the mouse, and simultaneous OPC fate analysis reveal that PTEN-AKT-GSK3b forms a persistent negative signaling pathway for OL development, in parallel with the AKT-mTORC1 pathway.
    1. Neuroscience

    Injury-induced perivascular niche supports alternative differentiation of adult rodent CNS progenitor cells

    Justyna Ulanska-Poutanen et al.
    Distinctive microenvironments within demyelinated white matter determine fate decisions of adult oligodendrocyte progenitor cells.

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