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The age-dependent shift of prefrontal excitation-inhibition (E-I) ratio toward inhibition causes sparser and decorrelated activity, while its impairment might relate to neurodevelopmental disorders.

Feedback-driven gain modulation provides a mechanism to generate and maintain invariant sensory representations in the presence of contextual changes by dynamically adapting feedforward sensory processing.

Transcriptomic comparison of inflammatory and steady-state osteoclasts reveals differences in their ability to sense their environment, which makes it possible to selectively inhibit inflammatory osteoclastogenesis and reduce bone loss in osteoporosis.

Functional dissection of a cluster of male-specific neurons in Drosophila reveals a neuronal circuit regulating male courtship in accordance with the internal drive state.

A cluster of neurons that integrates inhibitory and excitatory synaptic inputs from the mushroom body output neurons of the appetitive and aversive memory compartments, respectively, triggers upwind steering, mediating memory-driven olfactory navigation behaviors.

Increased stiffness of sensory neurons in the absence of microtubule acetylation renders mice profoundly insensitive to touch and pain.

A 7-dehydrocholesterol-derived oxysterol in SLOS was found to profoundly impact neurogenesis during cortical development by interacting with glucocorticoid receptor, which points to new therapeutic approaches for SLOS by targeting the activities of this oxysterol.

Mapping neuronal circuits is made substantially faster, simpler and more accurate with this extended toolkit of novel cell lines and vectors.

Vasoactive intestinal peptide-expressing GABAergic interneurons in cerebral cortex express the sodium channel subunit Nav1.1, and a defined subset of VIP interneurons are dysfunctional in a mouse model of Dravet syndrome.