907 results found
    1. Structural Biology and Molecular Biophysics
    2. Immunology and Inflammation

    Fluorescence Lifetime Imaging Microscopy reveals rerouting of SNARE trafficking driving dendritic cell activation

    Daniëlle Rianne José Verboogen et al.
    A novel microscopy-based assay shows that dendritic cells encountering pathogenic stimuli form increased complexes of specific SNARE proteins, driving release of large amounts of inflammatory cytokines.
    1. Immunology and Inflammation

    CD301b+ dendritic cells suppress T follicular helper cells and antibody responses to protein antigens

    Yosuke Kumamoto et al.
    CD301b dendritic cells potently suppress antibody responses by limiting the activity of follicular helper T cells and germinal center B cells.
    1. Human Biology and Medicine
    2. Immunology and Inflammation

    Dendritic cells loaded with FK506 kill T cells in an antigen-specific manner and prevent autoimmunity in vivo

    Dana E Orange et al.
    By using immune cells called dendritic cells to deliver drugs, it is possible to target and kill specific members of another class of immune cell, known as T cells, and to prevent these cells from attacking the body's own tissues in cases of autoimmune disease.
    1. Neuroscience

    Dendritic spikes in hippocampal granule cells are necessary for long-term potentiation at the perforant path synapse

    Sooyun Kim et al.
    A novel mechanism of local plasticity in the distal dendrites of hippocampal granule cells.
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    EBI2-mediated bridging channel positioning supports splenic dendritic cell homeostasis and particulate antigen capture

    Tangsheng Yi, Jason G Cyster
    The receptor EBI2 is essential for correctly positioning CD4+ dendritic cells in the spleen so that they can present blood-borne antigens to T cells and thereby provoke an antibody response.
    1. Immunology and Inflammation

    Glycan modification of antigen alters its intracellular routing in dendritic cells, promoting priming of T cells

    Ingeborg Streng-Ouwehand et al.
    Controlled neo-glycosylation of antigens can influence intracellular routing of antigens and the nature and strength of immune response, and should therefore be considered as a major determinant in the design of vaccines against cancer and infectious diseases.
    1. Immunology and Inflammation

    Plasmacytoid dendritic cells control dengue and Chikungunya virus infections via IRF7-regulated interferon responses

    Brian Webster et al.
    In vivo study of arbovirus infections reveals the dominant role of pDC IRF7-signaling in directing both type I and II IFN responses, and leading to viral control.
    1. Immunology and Inflammation

    High-endothelial cell-derived S1P regulates dendritic cell localization and vascular integrity in the lymph node

    Szandor Simmons et al.
    Impairment of the autocrine S1PR1-Gi signaling on HEVs results in high-endothelial cell apoptosis, reduced CCL21-secretion from HEVs, and cessation of HEV-DC interactions and lymphocyte immigration across the high-endothelial barrier.
    1. Neuroscience

    NG2 glial cells integrate synaptic input in global and dendritic calcium signals

    Wenjing Sun et al.
    NG2 glial cells respond to synaptic input with calcium signals in the absence of action potentials and process synaptic depolarizations with somatic and dendritic voltage gated channels.
    1. Immunology and Inflammation

    Antigen presentation kinetics control T cell/dendritic cell interactions and follicular helper T cell generation in vivo

    Robert A Benson et al.
    Temporal availability of antigen presentation by dendritic cells influences the differentiation of follicular helper T (Tfh) cells, which enhances germinal centre responses and induces protective immunity.

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