705 results found
    1. Medicine
    2. Microbiology and Infectious Disease

    Combination of inflammatory and vascular markers in the febrile phase of dengue is associated with more severe outcomes

    Nguyen Lam Vuong et al.
    Relationships of biomarkers with clinical outcome differed between children and adults and the best combinations associated with moderate/severe dengue comprised of six/seven vascular and immune biomarkers.
    1. Evolutionary Biology
    2. Microbiology and Infectious Disease

    Parallel evolution between genomic segments of seasonal human influenza viruses reveals RNA-RNA relationships

    Jennifer E Jones et al.
    Phylogenetic relationships between viral RNA segments are distinct between subtypes and lineages of seasonal human influenza A viruses and implicate RNA-RNA relationships as novel drivers of influenza virus evolution.
    1. Cell Biology
    2. Neuroscience

    TRPM7 is critical for short-term synaptic depression by regulating synaptic vesicle endocytosis

    Zhong-Jiao Jiang et al.
    Electrophysiological and live-cell imaging analyses identify a presynaptic function of Ca2+ influx via transient receptor potential melastatin 7 (TRPM7) channels.
    1. Genetics and Genomics
    2. Microbiology and Infectious Disease

    Variation in human herpesvirus 6B telomeric integration, excision, and transmission between tissues and individuals

    Michael L Wood et al.
    Human herpesvirus 6B can transition between telomere-integrated and free viral forms, and frequent telomere-loop-driven partial or complete viral genome excision events create mosaicism in germline carriers of inherited chromosomally integrated HHV-6B.
    1. Cell Biology

    Endoplasmic reticulum tubules limit the size of misfolded protein condensates

    Smriti Parashar et al.
    The endoplasmic reticulum (ER) uses ER tubules and specific ER autophagy machinery to prevent toxic, dominant-interfering, disease-causing, mutant proteins from entering the secretory pathway.
    1. Neuroscience

    Diverse inhibitory projections from the cerebellar interposed nucleus

    Elena N Judd et al.
    Inhibitory cerebellar feedback to the inferior olive is central to computational models of learning, but novel targets of these neurons identified here expand their potential roles.
    1. Chromosomes and Gene Expression
    2. Evolutionary Biology

    Enhanced Cas12a multi-gene regulation using a CRISPR array separator

    Jens P Magnusson et al.
    Cas12a CRISPR arrays are sensitive to the GC content of their spacers, but AT-rich separator sequences successfully remove this disruptive effect and enable enhanced multiplexed gene targeting and activation.
    1. Neuroscience

    Dorsal premammillary projection to periaqueductal gray controls escape vigor from innate and conditioned threats

    Weisheng Wang et al.
    Activity in the hypothalamic dorsal premammillary nucleus predicts future escape from threat, represents escape velocity, and controls escape velocity via a projection to the brainstem.
    1. Ecology
    2. Epidemiology and Global Health

    Physiology and ecology combine to determine host and vector importance for Ross River virus

    Morgan P Kain et al.
    The role host and vector species play in pathogen transmission cycles is best quantified by integrating species' physiological and ecological competence.
    1. Evolutionary Biology
    2. Immunology and Inflammation

    Evolution of pathogen tolerance and emerging infections: A missing experimental paradigm

    Srijan Seal et al.
    An integrated empirical paradigm tracing immune strategies, underlying mechanisms and infection outcomes across reservoir host-pathogen systems, their specific ecological contexts, life-history features, and coevolutionary dynamics can reveal the actual patterns and processes underlying spillover in the wild.

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