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Foxc1 dependent mesenchymal signalling drives embryonic cerebellar growth
Parthiv Haldipur et al.
The mesenchyme surrounding the developing brain plays a significant role in controlling the fundamental growth and patterning of the cerebellum, and misregulation of this signalling can lead to important neurodevelopmental disorders.
Upregulation of neurovascular communication through filamin abrogation promotes ectopic periventricular neurogenesis
Shauna L Houlihan et al.
Analyses based on the mouse model of a human genetic disease reveal that the neuron production of cerebral tissue can be boosted by escalated signaling between neural progenitors and the vasculature.
Deregulated FGF and homeotic gene expression underlies cerebellar vermis hypoplasia in CHARGE syndrome
Tian Yu et al.
Mutations in CHD7, which cause CHARGE syndrome, cause a reduction in FGF8 signalling and subsequent abnormalities in the cerebellar vermis in both mice and humans.
Stem Cells and Regenerative Medicine
Distinct origins and molecular mechanisms contribute to lymphatic formation during cardiac growth and regeneration
Dana Gancz et al.
Cardiac lymphatic vessels of heterogeneous origins and molecular signatures support cardiac growth and regeneration.
Hemodynamic-mediated endocardial signaling controls in vivo myocardial reprogramming
Manuel Gálvez-Santisteban et al.
The heart is able to sense and adaptively respond to environmental changes due to cardiac injury through flow-mediated mechanisms that regulate cardiomyocyte reprogramming and regeneration.
Hippocampus ghrelin signaling mediates appetite through lateral hypothalamic orexin pathways
Ted M Hsu et al.
A communication pathway linking memory processing and feeding behavior exists between the gut hormone ghrelin, the hippocampus and the hypothalamic neuropeptide orexin.
The Calcineurin-FoxO-MuRF1 signaling pathway regulates myofibril integrity in cardiomyocytes
Hirohito Shimizu et al.
Calcium overload in cardiomyocytes disrupts sarcomere integrity, by stimulating transcriptional upregulation of the E3 ubiquitin ligase MuRF1.
Physics of Living Systems
Origin and role of the cerebrospinal fluid bidirectional flow in the central canal
Olivier Thouvenin et al.
The combination of data and modelling shows the mechanisms underlying bidirectional flow of cerebrospinal fluid and its impact on long range transport in the CSF between brain and spinal cord.
Selection on mutators is not frequency-dependent
Yevgeniy Raynes, Daniel Weinreich
Contrary to intuition that the evolutionary fate of mutation rate modifying alleles is frequency-dependent, neither the strength nor the sign of selection on modifiers depends on initial frequency.
The flow responsive transcription factor Klf2 is required for myocardial wall integrity by modulating Fgf signaling
Seyed Javad Rasouli et al.
Endocardial Klf2 regulates cardiomyocyte adhesion and myocardial wall integrity by modulating FGF signaling in zebrafish.
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