The combination of cellular cryo-electron tomography, biochemistry, and mathematical modeling provides the first integrated structural model of the Alphavirus replication organelle.
Eugene A Katrukha, Daphne Jurriens ... Lukas C Kapitein
Quantitative super-resolution light microscopy reveals the relative abundance and three-dimensional organization of different microtubule subsets within dendrites of mammalian neurons.
Jui-Yi Hsieh, Brittany N Ulrich ... Diane M Papazian
Electrophysiological analysis and imaging in live zebrafish reveal that infant- and adult-onset SCA13 mutations have distinct effects on the electrical activity, development, and survival of cerebellar Purkinje cells.
A combination of cryo-electron microscopy, structure prediction, and evolutionary analyses reveal several functional states of the dynamic protein translocation machinery at the mammalian endoplasmic reticulum.
A neuroprotective role mediated by Strip1 maintains retinal ganglion cells during development, which ensures proper positioning of inner retinal neurons and preserves the laminar architecture of the inner retina.
Sonic Hedgehog is transported inside cytonemes with co-receptors that promote contact-mediated signal delivery to initiate rapid, receptor-dependent responses in recipient cells.
Sol Pose-Méndez, Paul Schramm ... Reinhard W Köster
Purkinje cell-specific ablation demonstrates regeneration of these neurons and functional recovery of the cerebellum during both larval and adult zebrafish.
The ability of COPI to bind polyubiquitin is a key determinant for SNARE incorporation into intracellular vesicles and for maintenance of a functional Golgi complex.
