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A novel folding machinery assists transmembrane proteins from the cytosolic side of the endoplasmic reticulum.

Discovery of potent covalent TEAD palmitoylation inhibitors that represents important tools to investigate the Hippo pathway.

Myristoylation of a secreted protein, identified in a global myristoylation analysis of the eukaryotic parasite Toxoplasma gondii, is important for host cell invasion.

Coupling between subcellular localization and protein turnover of a neuronal stress kinase, DLK, and its role in neuronal stress responses in Drosophila.

Genetic analysis of a CLN4 Drosophila model suggests that the disease-causing alleles act as dominant gain of function mutations that cause CSPα oligomerization and impair secretory and prelysosomal trafficking.

Crystal structural analysis reveals a novel reversible pan-inhibitor of TEA domains with enhanced potency adopts a unique binding mode.

This article reviews the latest studies that have used super-resolution microscopy and cluster analysis methodologies to study the mechanism of protein kinase signalling hubs and their organisation at nanoscale.

ORAI1 ion channel lipid modification is required for a proper immune synapse formation and T cell activation.

Functional reconstitution of a mammalian P2X7 receptor uncovers an intrinsic and lipid-dependent dye-permeable membrane pore.