An image-based multiplex autophagosome RNAi screen targeting all Rab GTPases as well as their GAPs and GEFs identifies the Rab GEF SMCR8 as multifaceted autophagy modulator, which regulates kinase activity and gene expression of ULK1.

The orphan receptor GPR158 is highly regulated by stress exposure and acts on key neuronal signaling pathways in the prefrontal cortex to control depressive-like behaviors.

A murine adoptive transfer model shows that binary IL-2 and graded CD25 expression tailor the T helper cell response to the antigen amount in vivo.

Stochastic mRNA and non-coding RNA hybridisation has a major impact on protein expression.

The VSG gene controls its monoallelic expression, and expression site activity determines developmental progression.

The well-established link between stress and depression could be due to the activity of a population of cells in prefrontal cortex that express a gene mutated in the rare disorder Wolfram syndrome.

The impact of changing gene expression noise on fitness reveals beneficial or deleterious effects in a stable environment depending how close the average expression level is to the fitness optimum.

Motor training decreased the unit synaptic response and suppressed induction of long-term depression at parallel fiber to Purkinje cell synapses in the cerebellum, supporting involvement of long-term depression in motor learning.

A novel method predicts cancer and immune cell types from bulk tumor gene expression data with the ability to consider uncharacterized and possibly highly variable cell types, which is validated in human genome.

In-lab evolution of synthetic promoters has revealed a novel general mechanism for de novo evolution of gene regulation, and highlights the crucial role of expression noise in this process.