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    1. Neuroscience

    Obesity causes selective and long-lasting desensitization of AgRP neurons to dietary fat

    Lisa R Beutler et al.
    Neurons that promote hunger become desensitized to dietary fat in obesity.
    1. Structural Biology and Molecular Biophysics
    2. Neuroscience

    Control of AMPA receptor activity by the extracellular loops of auxiliary proteins

    Irene Riva et al.
    Glutamate receptor auxiliary proteins exert their effects on receptor gating through two divergent extracellular loops, explaining subunit specificity and allowing the construction of null versions that form complexes normally but do not modify receptor gating.
    1. Structural Biology and Molecular Biophysics

    Regulatory switch at the cytoplasmic interface controls TRPV channel gating

    Lejla Zubcevic et al.
    C-terminal domain of thermoTRPV channels regulates channel gating at the cytoplasmic interface through a switch-like process.
    1. Neuroscience

    Stimulus salience determines defensive behaviors elicited by aversively conditioned serial compound auditory stimuli

    Sarah Hersman et al.
    Perceived imminence of threat and resulting intensity of defensive responses during serial compound stimulus conditioning are determined by auditory stimulus salience, not cue sequence as recently reported.
    1. Neuroscience

    Auxiliary subunits of the CKAMP family differentially modulate AMPA receptor properties

    Paul Farrow et al.
    Three AMPAR interacting proteins – namely CKAMP39, CKAMP52 and CKAMP59 – together with the previously characterized CKAMP44, constitute a new family of auxiliary subunits that are distinct from other families of AMPAR interacting proteins.
    1. Neuroscience

    Dopamine neuron dependent behaviors mediated by glutamate cotransmission

    Susana Mingote et al.
    The conditional reduction of glutaminase in mouse dopamine neurons selectively attenuates glutamate cotransmission at phasic frequencies, revealing the role of dopamine neuron glutamate cotransmission in the attribution of motivational salience.
    1. Neuroscience

    Mechanisms and functional roles of glutamatergic synapse diversity in a cerebellar circuit

    Valeria Zampini et al.
    Unipolar brush cells within the cerebellum show highly variable responses to input from the inner ear, and this variability boosts the learning of motor skills.
    1. Structural Biology and Molecular Biophysics

    Crystal structure and dynamics of a lipid-induced potential desensitized-state of a pentameric ligand-gated channel

    Sandip Basak et al.
    Polyunsaturated fatty acids enhance desensitization in pentameric ligand-gated ion channels.
    1. Structural Biology and Molecular Biophysics
    2. Cell Biology

    Atypical calcium regulation of the PKD2-L1 polycystin ion channel

    Paul G DeCaen et al.
    Outward calcium ion currents desensitize the human PKD2-L1 ion channel via a mechanism that is independent of cytosolic motifs.
    1. Neuroscience

    A predictive focus of gain modulation encodes target trajectories in insect vision

    Steven D Wiederman et al.
    Visual neurons in the dragonfly predict the path of a moving target, even when it is occluded or crosses from one eye to the other.