Altered lymphocyte dynamics after hematopoietic stem cell transplantation cannot solely be explained by low lymphocyte numbers.

Cells use two interdigitated biosynthetic pathways that can be regulated independently to produce diverse bioactive sterols.

Metabolic labelling reveals complex proteome dynamics in tendon, with faster turnover of proteins in the glycoprotein-rich interfascicular matrix compared to the collagen-rich fascicular matrix.

The first-in-class kinase inhibitor, Ibrutinib, destabilizes its autoinhibited Bruton’s tyrosine kinase (BTK) target, and a remote resistance mutation causes global structural changes that activate BTK catalytic activity.

Pulsed-labeling hydrogen exchange on the ribonuclease H family show that the major folding intermediate is conserved over three billion years of evolution, but the path leading to this intermediate varies.

Protein dynamics signatures in ageing collagen-rich tissues that are central to frequent age-related diseases such as osteoporosis and osteoarthritis.

SARS-CoV-2 spike protein binding to receptor angiotensin-converting enzyme 2 allosterically enhances furin proteolysis at distal S1/S2 cleavage sites.

The first structural and biochemical study of the role of the ATP-cone in anaerobic ribonucleotide reductases shows that dATP allosterically prevents transfer of a glycyl radical to the substrate.

The dynamical transition between a protein and its surface water is decoupled.

The c-terminus of PI3K plays a key role in regulating kinase activity, with c-terminal disease-linked mutations leading to either activation or inhibition, which reveal a path to specific inhibitors.