Evolutionary novelty is promoted by a macroevolutionary pulse of developmental plasticity, but is enhanced by secondary fixation, which permits developmental character release and further morphological exploration.
Global transcriptome changes, particularly alternative splicing, are highly dynamic the first 2 weeks after birth, and the example of calcineurin A splicing exemplifies the importance of alternative splicing during skeletal muscle development.
The connectivity structure of a nociceptive circuit is precisely maintained over Drosophila larval development through cell type-specific increases in synaptic contacts as measured from electron microscopy reconstructions, while individual neurons grow five-fold in size and number of synapses.
The Apelin receptor acts as a rheostat to ensure that the proper levels of Nodal signaling are achieved for proper cell fate specification at the onset of gastrulation, in particular for cardiac progenitor development.
The diversity of electrophysiological phenotypes of neurons in a functional network increases over development, but can be modulated, and even reduced by sensory experience; allowing them to adapt to a changing and growing brain.