Nf1 is required during early, but not late, cerebellar development to facilitate neuronal lamination, providing a potential therapeutic prevention strategy for NF1-associated developmental abnormalities.
Combined evidence of human genetics, in vitro cardiomyocyte differentiation, and mouse model indicates that SORBS2 is a regulator of second heart field development and its deficiency causes seemingly opposite atrial septal defects.
Quantitative analyses associating the morphology of developing organs with dynamic gene expression patterns can reveal biological phenomena that cause malformations and malfunction but remain elusive to traditional qualitative assessments.
Experiments in zebrafish reveal a new role for a critical hypothalamic transcription factor, orthopedia, in controlling developmental neuropeptide balance in a discrete oxytocin-producing neuronal circuit whose disrupted development affects social behavior.
Single cell RNA sequencing reveals that mouse embryonic stem cells can be differentiated into the same terminal motor neuron state via distinct differentiation paths, one of which includes a surprising intermediate state not found in embryos.
Glycolysis is locally enhanced and redirected in zebrafish to generate lactate, which functions as a signaling molecule to fully activate Fgf target genes required for proper sensory and neural development.